You are not logged in. Please LOG IN to view the weekly content using the black button on the left. 

Please note that the Course Modules will be locked until after Orientation on October 29, 2021.

IC 2022 Weekly Distance Learning Modules

Search Items

Nov 1-5, 2021
Week 1: Fundamentals of Genetics

VIEW CONTENT
Module Objectives

Basic Genetics Primer, Part 1

Objectives

  • Define the basic principles of gene structure, function, and regulation
  • Appreciate the nature and consequences of major types of gene mutations

Basic Genetics Primer, Part 2

Objectives

  • Outline the principles of Mendelian inheritance
  • Identify the features of incomplete penetrance and variable expressivity
  • Recognize how genetic mechanisms such as de novo mutations, mosaicism and imprinting can affect the pattern of cancer in a family

The Basic Science of Cancer Genetics

Objectives

  • Distinguish the differences between somatic and germline mutations
  • Describe the roles of oncogenes and tumor suppressor genes in signal transduction and cell cycle control
  • Review the mechanisms of DNA damage


Nov 8-12, 2021
Week 2: Essential Components of the GCRA Practice

VIEW CONTENT
Module Objectives

The Fundamentals of GCRA

Objectives

  • Describe fundamentals of the genetic cancer risk assessment (GCRA) process
  • Take a comprehensive cancer family history
  • Explain the importance of and strategies for confirming key cancers
  • Identify sporadic, familial, and hereditary cancer patterns

Documenting the Cancer Family History and the Fundamentals of GCRA

Objectives

  • Recognize the importance of eliciting, documenting and verifying the patient family history
  • Collect family history information, focusing on details and questions relevant to cancer history documentation
  • Draw a 3-4 generation pedigree using standard pedigree nomenclature and symbols 
  • Identify questionable or incomplete information that will need further verification to assess cancer risk in the family 
  • Demonstrate skills associated with proficiency in collecting and documenting the family history of cancers

Reading the Pathology Report through the Genomics Lens

Objectives

  • Apply reading and interpreting pathology reports to define cancer stage and extract information on histology/molecular features
  • Describe the roles of other diagnostic data (imaging, CT scans, blood markers)

Nov 15-19, 2021
Week 3: Genetic/Genomic Testing

VIEW CONTENT
Module Objectives

Laboratory Methods for Inherited Cancer Susceptibilities

Objectives

  • Identify the methods, benefits, and limitations of different types of NGS cancer panels
  • Recognize approaches to variant interpretation and reporting
  • Apply different types of genetic tests to clinical vignettes

Characterization and Clinical Interpretation of Germline Genomic Variants

Objectives

  • Review types of genetic variants
  • Outline the categories of variant classification established by the ACMG
  • Describe the methods, resources, and tools used to classify variants
  • Discuss approaches to re-classifying variants of uncertain significance (VUS)


Mutation Nomenclature: Reading and Interpreting Genetic Test Results

Objectives

  • Recognize and describe various types of mutations
  • Distinguish between different types of mutation nomenclature
  • Interpret a genetic test report

Nov 29-Dec 2, 2021
Week 4: Hereditary Breast and Ovarian Cancer Syndromes, Part 1

VIEW CONTENT
Module Objectives

Hereditary Breast and Ovarian Cancer Syndromes, Part 1 & Part 2

Objectives

  • Recognize features of hereditary breast/breast and ovarian cancer syndromes
  • Profile key scientific history as it informs the present
  • Describe the established and emerging genetic etiologies of breast and ovarian cancer
  • Review the impact of founder mutations and variants of uncertain significance
  • Understand the benefits and limitations of genetic analysis for hereditary breast/breast ovarian cancer, with a focus on multigene assays

Hereditary Breast/Ovarian Cancer Risk Assessment

Objectives

  • Recognize and apply mutation probability and empiric risk assessment models for breast cancer
  • Formulate an evaluation & management plan

Dec 6-10, 2021
Week 5: Hereditary Breast and Ovarian Cancer Syndromes, Part 2

VIEW CONTENT
Module Objectives

Clinical Management of Hereditary Breast & Ovarian Cancers, Part 1

Objectives

  • Describe the methods and efficacy of  breast and ovarian cancer screening tools
  • Describe the methods and efficacy of breast and ovarian cancer surgical risk reduction
  • Review the NCCN guidelines for high-risk cancer screening and management
  • Recognize the timing of GCRA and impact on surgical decisions 
  • Discuss targeted treatment options for patients with germline HRD mutations 

Clinical Management of Hereditary Breast & Ovarian Cancers, Part 2

Objectives

  • Identify tools and strategies for personalized on-surgical breast cancer risk reduction
  • Describe the benefits and risks of chemopreventive risk reduction strategies and appropriateness for age, life phase and risk level
  • Review evidence related to lifestyle interventions to reduce breast cancer risk (diet, exercise, etc) 
  • Recognize approaches for  testing new interventions for breast cancer risk reduction.

Other Genes on Panels: "Managing Moderate Penetrance"

Objectives

  • Describe the differences between a high, moderate, and low penetrance cancer susceptibility genes.
  • Counsel a patient about moderate and low penetrance cancer susceptibility genes found on routine clinical testing.
  • Identify that moderate and low penetrance cancer susceptibility genes may not track with the family history of cancer.
  • Recognize that cancer susceptibility genes on clinical panels are not always actionable.

Dec 13-17, 2021
Week 6: Hereditary Gastrointestinal Syndromes, Part 1

VIEW CONTENT
Module Objectives

Hereditary Gastrointestinal Cancer Syndromes, Part 1: Lynch Syndrome

Objectives

  • Recognize the features of hereditary gastrointestinal and other cancers associated with Lynch Syndrome
  • Discuss the methods and limitations of tumor screening for Lynch syndrome
  • Identify the features and mode of inheritance of Constitutional Mismatch Repair Deficiency (CMMRD)
  • Recognize the characteristics of Familial Colorectal Cancer Type X


Hereditary Gastrointestinal Cancer Syndromes, Part 2: Polyposis

Objectives

  • Identify the features distinguishing different hereditary polyposis syndromes
  • Recognize the association between polyp histology and potential germline genetic predisposition to a polyposis syndrome
  • Discern the features of different polyposis syndromes, including: Familial adenomatous polyposis; MutYH-associated polyposis; Hamartomatous polyposis syndromes; Serrated polyposis syndrome


Hereditary Gastrointestinal Cancer Syndromes, Part 3: Gastric Pancreatic

Objectives

  • Recognize the features of hereditary gastric cancers
  • Recognize the features of hereditary pancreatic cancers
  • Apply appropriate germline genetic testing strategies for hereditary gastrointestinal syndromes

Jan 3-7, 2022
Week 7: Hereditary Gastrointestinal Syndromes, Part 2

VIEW CONTENT
Module Objectives

Significance and Practical Applications for Tumor Phenotyping (IHC/MSI) Hereditary Cancer Risk Assessment

Objectives

  • Determine which cases of CRC have defective mismatch repair
  • Screen for Lynch syndrome among newly diagnosed CRC & EC patients
  • Discuss OSU clinical experience doing IHC on all newly diagnosed CRC & EC patients
  • Review EGAPP recommendations


Clinical Management of Hereditary Gastrointestinal Cancers

Objectives

  • Recognize standard of care screening guidelines for individuals with increased risks for gastrointestinal cancers associated with hereditary cancer syndromes, including Lynch, Familial Adenomatous Polyposis, Peutz-Jeghers and Juvenile  Polyposis syndromes)
  • Identify established and emerging surgical and chemopreventive risk management recommendations and options for hereditary gastrointestinal cancers
  • Understand the spectrum and limits of established and emerging screening and risk management for individuals with hereditary risk for diffuse gastric and pancreatic cancers

Jan 10-14, 2022
Week 8: Pediatric, Hematologic, and Genodermatosis Syndromes

VIEW CONTENT
Module Overview

Pediatric Cancer Syndromes

Objectives

  • Recognize clinical features of hereditary cancer syndromes with pediatric manifestations
  • Recognize the conditions under which a pediatric cancer patient should be referred to Clinical Genetics, and to educate providers of the sign of pediatric hereditary syndromes
  • Identify genetic counseling and testing issues associated with pediatric hereditary cancer syndromes
  • Apply appropriate germline genetic testing strategies for herediary pediatric cancer syndromes 
  • Provide education on hereditary cancer syndromes with pediatric manifestations to parents, patients and providers in age appropriate manner

Hereditary Hematologic Cancer Syndromes

Objectives

  • Recognize the basics of hematologic malignancies
  • Understand the currently known hereditary hematologic malignancy syndromes
  • Distinguish the unique needs for genetic testing in the setting of hematologic malignancies

Hereditary Genodermatoses

Objectives

  • Define disease characteristics of hereditary syndromes classified as genodermatoses
  • Identify the genes associated with hereditary syndromes that have cutaneous manifestations 
  • Recognize cancer risks associated with hereditary genodermatoses syndromes



Jan 17-21, 2022
Week 9: Hereditary Endocrine and Genitourinary Cancer Syndromes

VIEW CONTENT
Module Overview

Hereditary Endocrine Neoplasias

Objectives

  • Recognize clinical features of hereditary endocrine neoplasia syndromes
  • Understand risks, benefits, and limitations of genetic testing
  • Identify resources to inform risk management for individuals with hereditary endocrine neoplasias

Genitourinary Cancer Syndromes

Objectives

  • Recognize inherited urologic disorders associated with kidney cancer 
  • Distinguish renal tumor pathologies associated with several inherited kidney cancer syndromes
  • Identify appropriate kidney cancer patients for genetic counseling and testing

Hereditary Prostate Cancer

Objectives

  • Describe the genetic etiologies of hereditary prostate cancer
  • Recognize features warranting genomic evaluation associated with prostate cancer
  • Explain the methods and limitations of genetic analysis for hereditary prostate cancer

Jan 24-28, 2022
Week 10: Tumor/Germline Testing; Understanding and Interpreting Clonal Hematopoiesis

VIEW CONTENT
Module Overview


Tumor/Germline Analysis in GCRA Practice, Part 1 & 2

Objectives

  • Compare the benefits and challenges of somatic panel, germline panel and paired somatic/germline sequencing
  • Identify issues related to incidental findings in cancer sequencing.
  • Discriminate strategies used to interpret genomic data
  • Examine ways that genomic data are changing cancer treatment paradigms.
  • Discuss some of the patient, provider, and system-level challenges to genomic test integration. 

Navigating Complex Genetic Test Results - Clonal Hematapoesis

Objectives

  • Review the various possible mechanisms of both germline and somatic mosaicism
  • Identify the various mechanisms that can be associated with an altered allelic fraction in a germline genetic test
  • Discuss approaches to interpreting, further evaluating and following up on genetic test results reporting low allelic fractions

Jan 31-Feb 4, 2022
Week 11: Ethical, Legal, and Social Implications; Psychosocial and Family Dynamics

VIEW CONTENT
Module Overview

Ethical, Legal, and Social Issues in Cancer Genetics

Objectives

  • Recognize ethical, legal and social issues relevant to cancer genetics counseling and testing
  • Apply bioethical principles to counseling challenges
  • Identify emerging legislation protecting against genetic discrimination

Pyscho-social and Family Dynamics of Hereditary Cancers 

Objectives

  • Recognize key psychological principles and how they generalize across hereditary cancer syndromes
  • Discuss  how psychological factors may interact with specific features of hereditary risk
  • Review how these processes may effect emotional adjustment, decision-making,quality of life
  • Identify family- and individual-level challenges commonly encountered in working with familial risk patients
  • Review brief assessments and tools that can be incorporated into cancer risk consultations Identify red flags that indicate consideration of referral for psychological support

Feb 7-11, 2022
Week 12: GCRA Counseling Strategies

VIEW CONTENT
Module Overview

Cancer Risk Assessment Counseling Strategies

Objectives

  • Observe the application of cancer risk assessment and counseling skills in the setting of mock initial and follow up GCRA consultation sessions
  • Recognize the key elements of a comprehensive GCRA counseling process
  • Review the essential components of the informed consent process for genetic testing
  • Identify how to address ethical, legal and social issues with patients and families
  • Recognize key issues related to genetic test results interpretation, disclosure and communication of personalized risk management recommendations

Electives



The Intensive Course in Cancer Risk Assessment is supported in part by funding from the National Cancer Institute of the National Institutes of Health under award numbers R25 CA112486 and R25 CA171998