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IC 2022 Weekly Distance Learning Modules
Nov 1-5, 2021
Week 1: Fundamentals of Genetics
Module Objectives
Basic Genetics Primer, Part 1
Objectives
- Define the basic principles of gene structure, function, and regulation
- Appreciate the nature and consequences of major types of gene mutations
Basic Genetics Primer, Part 2
Objectives
- Outline the principles of Mendelian inheritance
- Identify the features of incomplete penetrance and variable expressivity
- Recognize how genetic mechanisms such as de novo mutations, mosaicism and imprinting can affect the pattern of cancer in a family
The Basic Science of Cancer Genetics
Objectives
- Distinguish the differences between somatic and germline mutations
- Describe the roles of oncogenes and tumor suppressor genes in signal transduction and cell cycle control
- Review the mechanisms of DNA damage
Speaker(s)
Lauren Gima, MS, CGC, Senior Genetic Counselor
Nov 8-12, 2021
Week 2: Essential Components of the GCRA Practice
Module Objectives
The Fundamentals of GCRA
Objectives
- Describe fundamentals of the genetic cancer risk assessment (GCRA) process
- Take a comprehensive cancer family history
- Explain the importance of and strategies for confirming key cancers
- Identify sporadic, familial, and hereditary cancer patterns
Documenting the Cancer Family History and the Fundamentals of GCRA
Objectives
- Recognize the importance of eliciting, documenting and verifying the patient family history
- Collect family history information, focusing on details and questions relevant to cancer history documentation
- Draw a 3-4 generation pedigree using standard pedigree nomenclature and symbols
- Identify questionable or incomplete information that will need further verification to assess cancer risk in the family
- Demonstrate skills associated with proficiency in collecting and documenting the family history of cancers
Reading the Pathology Report through the Genomics Lens
Objectives
- Apply reading and interpreting pathology reports to define cancer stage and extract information on histology/molecular features
- Describe the roles of other diagnostic data (imaging, CT scans, blood markers)
Speaker(s)
Bita Nehoray, MS, CGC, Senior Genetic Counselor
Nov 15-19, 2021
Week 3: Genetic/Genomic Testing
Module Objectives
Laboratory Methods for Inherited Cancer Susceptibilities
Objectives
- Identify the methods, benefits, and limitations of different types of NGS cancer panels
- Recognize approaches to variant interpretation and reporting
- Apply different types of genetic tests to clinical vignettes
Characterization and Clinical Interpretation of Germline Genomic Variants
Objectives
- Review types of genetic variants
- Outline the categories of variant classification established by the ACMG
- Describe the methods, resources, and tools used to classify variants
- Discuss approaches to re-classifying variants of uncertain significance (VUS)
Mutation Nomenclature: Reading and Interpreting Genetic Test Results
Objectives
- Recognize and describe various types of mutations
- Distinguish between different types of mutation nomenclature
- Interpret a genetic test report
Speaker(s)
Colin Pritchard, MD, PhD, Assistant Professor
Nov 29-Dec 2, 2021
Week 4: Hereditary Breast and Ovarian Cancer Syndromes, Part 1
Module Objectives
Hereditary Breast and Ovarian Cancer Syndromes, Part 1
Hereditary Breast and Ovarian Cancer Syndromes, Part 2: Other Genes on Panels
Objectives
- Recognize features of hereditary breast/breast and ovarian cancer syndromes
- Profile key scientific history as it informs the present
- Describe the established and emerging genetic etiologies of breast and ovarian cancer
- Review the impact of founder mutations and variants of uncertain significance
- Understand the benefits and limitations of genetic analysis for hereditary breast/breast ovarian cancer, with a focus on multigene assays
Hereditary Breast/Ovarian Cancer Risk Assessment
Objectives
- Recognize and apply mutation probability and empiric risk assessment models for breast cancer
- Formulate an evaluation & management plan
Speaker(s)
Jeffrey Weitzel, MD, Professor of Oncology and Population Sciences
Dec 6-10, 2021
Week 5: Hereditary Breast and Ovarian Cancer Syndromes, Part 2
Module Objectives
Clinical Management of Hereditary Breast & Ovarian Cancers, Part 1
Objectives
- Describe the methods and efficacy of breast and ovarian cancer screening tools
- Describe the methods and efficacy of breast and ovarian cancer surgical risk reduction
- Review the NCCN guidelines for high-risk cancer screening and management
- Recognize the timing of GCRA and impact on surgical decisions
- Discuss targeted treatment options for patients with germline HRD mutations
Clinical Management of Hereditary Breast & Ovarian Cancers, Part 2
Objectives
- Identify tools and strategies for personalized on-surgical breast cancer risk reduction
- Describe the benefits and risks of chemopreventive risk reduction strategies and appropriateness for age, life phase and risk level
- Review evidence related to lifestyle interventions to reduce breast cancer risk (diet, exercise, etc.)
- Recognize approaches for testing new interventions for breast cancer risk reduction.
Dec 13-17, 2021
Week 6: Hereditary Gastrointestinal Syndromes, Part 1
Module Objectives
Hereditary Gastrointestinal Cancer Syndromes, Part 1: Lynch Syndrome
Objectives
- Recognize the features of hereditary gastrointestinal and other cancers associated with Lynch Syndrome
- Discuss the methods and limitations of tumor screening for Lynch syndrome
- Identify the features and mode of inheritance of Constitutional Mismatch Repair Deficiency (CMMRD)
- Recognize the characteristics of Familial Colorectal Cancer Type X
Hereditary Gastrointestinal Cancer Syndromes, Part 2: Polyposis
Objectives
- Identify the features distinguishing different hereditary polyposis syndromes
- Recognize the association between polyp histology and potential germline genetic predisposition to a polyposis syndrome
- Discern the features of different polyposis syndromes, including: Familial adenomatous polyposis; MutYH-associated polyposis; Hamartomatous polyposis syndromes; Serrated polyposis syndrome
Hereditary Gastrointestinal Cancer Syndromes, Part 3: Gastric Pancreatic
Objectives
- Recognize the features of hereditary gastric cancers
- Recognize the features of hereditary pancreatic cancers
- Apply appropriate germline genetic testing strategies for hereditary gastrointestinal syndromes
Jan 3-7. 2022
Week 7: Hereditary Gastrointestinal Syndromes, Part 2
Module Objectives
Significance and Practical Applications for Tumor Phenotyping (IHC/MSI) in Hereditary Cancer Risk Assessment
Objectives
- Determine which cases of CRC have defective mismatch repair
- Screen for Lynch syndrome among newly diagnosed CRC & EC patients
- Discuss OSU clinical experience doing IHC on all newly diagnosed CRC & EC patients
- Review EGAPP recommendations
Clinical Management of Hereditary Gastrointestinal Cancers
Objectives
- Recognize standard of care screening guidelines for individuals with increased risks for gastrointestinal cancers associated with hereditary cancer syndromes, including Lynch, Familial Adenomatous Polyposis, Peutz-Jeghers and Juvenile Polyposis syndromes)
- Identify established and emerging surgical and chemopreventive risk management recommendations and options for hereditary gastrointestinal cancers
- Understand the spectrum and limits of established and emerging screening and risk management for individuals with hereditary risk for diffuse gastric and pancreatic cancers
Jan 10-14, 2022
Week 8: Pediatric, Hematologic, and Genodermatosis Syndromes
Module Overview
Pediatric Cancer Syndromes
Objectives
- Recognize clinical features of hereditary cancer syndromes with pediatric manifestations
- Recognize the conditions under which a pediatric cancer patient should be referred to Clinical Genetics
- Identify genetic counseling and testing issues associated with pediatric hereditary cancer syndromes
- Apply appropriate germline genetic testing strategies for herediary pediatric cancer syndromes
- Provide education on hereditary cancer syndromes with pediatric manifestations to parents, patients and providers in age appropriate manner
Hereditary Hematologic Cancer Syndromes
Objectives
- Recognize the basics of hematologic malignancies
- Understand the currently known hereditary hematologic malignancy syndromes
- Distinguish the unique needs for genetic testing in the setting of hematologic malignancies
Hereditary Genodermatoses
Objectives
- Define disease characteristics of hereditary syndromes classified as genodermatoses
- Identify the genes associated with hereditary syndromes that have cutaneous manifestations
- Recognize cancer risks associated with hereditary genodermatoses syndromes
Hereditary Melanoma
Objectives
- Identify characteristics of hereditary melanoma and when to consider genetic testing
- Recognize the genes associated with hereditary melanoma
- Discuss clinical characteristics associated with CDKN2A gene and management recommendations
Jan 17-21, 2022
Week 9: Hereditary Endocrine and Genitourinary Cancer Syndromes
Module Overview
Hereditary Endocrine Neoplasias
Objectives
- Recognize clinical features of hereditary endocrine neoplasia syndromes
- Understand risks, benefits, and limitations of genetic testing
- Identify resources to inform risk management for individuals with hereditary endocrine neoplasias
Genitourinary Cancer Syndromes
Objectives
- Recognize inherited urologic disorders associated with kidney cancer
- Distinguish renal tumor pathologies associated with several inherited kidney cancer syndromes
- Identify appropriate kidney cancer patients for genetic counseling and testing
Hereditary Prostate Cancer
Objectives
- Describe the genetic etiologies of hereditary prostate cancer
- Recognize features warranting genomic evaluation associated with prostate cancer
- Explain the methods and limitations of genetic analysis for hereditary prostate cancer
Jan 24-28, 2022
Week 10: Tumor/Germline Testing; Understanding and Interpreting Clonal Hematopoiesis
Module Overview
Tumor/Germline Analysis in GCRA Practice, Part 1 & 2
Objectives
- Compare the benefits and challenges of somatic panel, germline panel and paired somatic/germline sequencing
- Identify issues related to incidental findings in cancer sequencing.
- Discriminate strategies used to interpret genomic data
- Examine ways that genomic data are changing cancer treatment paradigms.
- Discuss some of the patient, provider, and system-level challenges to genomic test integration.
Navigating Complex Genetic Test Results - Clonal Hematapoesis
Objectives
- Review the various possible mechanisms of both germline and somatic mosaicism
- Identify the various mechanisms that can be associated with an altered allelic fraction in a germline genetic test
- Discuss approaches to interpreting, further evaluating and following up on genetic test results reporting low allelic fractions
Jan 31-Feb 4, 2022
Week 11: Ethical, Legal, and Social Implications; Psychosocial and Family Dynamics
Module Overview
Ethical, Legal, and Social Issues in Cancer Genetics
Objectives
- Recognize ethical, legal and social issues relevant to cancer genetics counseling and testing
- Apply bioethical principles to counseling challenges
- Identify emerging legislation protecting against genetic discrimination
Pyscho-social and Family Dynamics of Hereditary Cancers
Objectives
- Recognize key psychological principles and how they generalize across hereditary cancer syndromes
- Discuss how psychological factors may interact with specific features of hereditary risk
- Review how these processes may effect emotional adjustment, decision-making,quality of life
- Identify family- and individual-level challenges commonly encountered in working with familial risk patients
- Review brief assessments and tools that can be incorporated into cancer risk consultations Identify red flags that indicate consideration of referral for psychological support
Feb 7-11, 2022
Week 12: GCRA Counseling Strategies
Module Overview
Cancer Risk Assessment Counseling Strategies
Objectives
- Observe the application of cancer risk assessment and counseling skills in the setting of mock initial and follow up GCRA consultation sessions
- Recognize the key elements of a comprehensive GCRA counseling process
- Review the essential components of the informed consent process for genetic testing
- Identify how to address ethical, legal and social issues with patients and families
- Recognize key issues related to genetic test results interpretation, disclosure and communication of personalized risk management recommendations
Electives
The Intensive Course in Cancer Risk Assessment is supported in part by funding from the National Cancer Institute of the National Institutes of Health under award numbers R25 CA112486 and R25 CA171998
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