Judy Garber, MD, MPH

Director, Center for Cancer Genetics and Prevention

Dana Farber Cancer Institute

Dr. Garber is the Director of the Cancer Genetics and Prevention Disease Center at Dana-Farber Cancer Institute and a Professor of Medicine at Harvard Medical School. Dr. Garber conducts research in clinical cancer genetics, with a special focus in the genetics of breast cancer. She has played a major role in the development of national guidelines in cancer genetics. She is also a leader in research into the characteristics and treatment of triple negative or basal-like breast cancer, the most common form in women with BRCA1 mutations. Her translational research focuses on the evaluation of novel agents targeting DNA repair defects in breast cancer, including PARP inhibitors for treatment and prevention of breast cancer and other BRCA-associated cancers.

 In 2011-2012, Dr. Garber was the President of American Association for Cancer Research (AACR), the largest organization of cancer researchers in the world. She is a member of the National Cancer Advisory Board and was recently elected to the Institute of Medicine.

Carol Fabian, MD

Director, Breast Cancer Prevention & Survivorship Centers

KU Breast Cancer Prevention Center

Dr. Carol Fabian is a breast medical oncologist, University Distinguished Professor, and holds the Morris Endowed Chair in Cancer Prevention at the University of Kansas Medical Center.  She received her medical degree from the University of Kansas in 1972, and fellowship in Medical Oncology at the University of Kansas in 1977.  She is board certified in both Internal Medicine and Medical Oncology.  She  has been on the faculty in the Division of Medical Oncology since 1977 and has served in multiple capacities including Medical Director of the Cancer Center, Founder and Director of the Breast Cancer Prevention and Survivorship Research Center, Leader or co-Leader of the Cancer Prevention Program, and Associate Director of Clinical Research in the NCI Designated Cancer Center.

Key:

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Clinical Management of Hereditary Breast & Ovarian Cancers, Part 1
Open to view video.
Open to view video. ~52 minutes. Review NCCN guidelines for high-risk cancer screening and management. Identify the methods and efficacy of breast and gynecologic screening tools. Identify the methods and efficacy of breast and ovarian surgical risk reduction. Understand the potential impact of cancer risk assessment and genetic testing related to surgical decision-making and timing. Recognize emerging role of targeted therapies for high-risk individuals (e.g., BRCA, PTEN, etc.).
Clinical Management of Hereditary Breast & Ovarian Cancers, Part 2
Open to view video.
Open to view video. ~46 minutes. Review chemopreventive clinical trials pertinent to individuals at high risk for developing cancer. Apply these data appropriately to individuals at genetic versus empiric high risk. Describe chemoprevention studies currently open for enrollment.