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HOMEPAGE

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Instruction
2 Learning Modules,
1 Elective Module

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Time
1.82 Hours

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Tasks
1 Quiz,
1 Evaluation

Hereditary Gastrointestinal Cancer Syndromes, Polyposis

Objectives

  • Identify the features distinguishing different hereditary polyposis syndromes
  • Recognize the association between polyp histology and potential germline genetic predisposition to a polyposis syndrome
  • Discern the features of different polyposis syndromes, including: Familial adenomatous polyposis; MutYH-associated polyposis; Hamartomatous polyposis syndromes; Serrated polyposis syndrome

Hereditary Gastrointestinal Cancer Syndromes, Gastric Pancreatic

Objectives

  • Recognize the features of hereditary gastric cancers
  • Recognize the features of hereditary pancreatic cancers
  • Apply appropriate germline genetic testing strategies for hereditary gastrointestinal syndromes
Gregory Idos MD, MS

Gregory Idos MD, MS

Associate Clinical Professor, Department of Medicine, Division of Gastroenterology

City of Hope

Dr. Idos is a board-certified gastroenterologist and trained cancer geneticist, who specializes in the care of patients with Lynch syndrome, FAP (familial adenomatous polyposis) and other inherited syndromes. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients.

A UCLA graduate, Dr. Idos has a master’s degree from Keck School of Medicine of USC. He received his medical degree at University of Vermont, continued his residency training at USC and completed his gastroenterology fellowship at Brigham and Women’s Hospital at Harvard. Dr. Idos is an associate clinical professor in Division of Gastroenterology and leads one of the largest multicenter studies examining the benefits and harms of “multiplex” gene panel testing. His research also focuses on the evaluation of novel technologies with the goal of providing new tools for hereditary cancer risk assessment and the development of novel cellular models to elucidate the fundamental mechanisms of microsatellite instability and Lynch syndrome.

Sonia S. Kupfer, MD

Sonia S. Kupfer, MD

Assistant Professor of Medicine

University of Chicago Medical Center

Sonia S. Kupfer is an Assistant Professor of Medicine in the Section of Gastroenterology at the University of Chicago Medical Center, Chicago, IL. She is the Director of the Gastrointestinal Cancer Risk and Prevention Clinic and co-Director of the Comprehensive Cancer Risk and Prevention clinic at the University of Chicago. She is funded by a K08 career development award from the NIH/NCI to study colorectal cancer genetic susceptibility variants in African Americans. Dr. Kupfer is also currently investigating genetics related to chemopreventive agents for colorectal cancer, notably vitamin D. In addition to her translational research, Dr. Kupfer is actively engaged in clinical studies in high-risk colorectal cancer primarily Lynch syndrome. Her clinical work focuses on hereditary GI cancer evaluation, testing and management. She also has served as co-Director of two CME conferences on genomics. Dr. Kupfer received her undergraduate degree from Yale University and then completed medical school, residency, chief residency and gastroenterology fellowship training at the University of Chicago. She is originally from a northern suburb of Chicago and currently resides in the Hyde Park area with her husband, an art dealer, and her two children.

Rachelle Manookian, MS, CGC

Rachelle Manookian, MS, CGC

Genetic Counselor

Children's Hospital of Los Angeles

RACHELLE MANOOKIAN, MS, CGC is a licensed and board-certified cancer genetic counselor specializing in pediatric oncology at Children’s Hospital Los Angeles (CHLA). She was previously with the Division of Clinical Cancer Genomics at City of Hope, and before that, a general genetic counselor at the West VA Medical Center. She brings her growing expertise in medical education to her role as an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics master’s programs. She serves as a faculty mentor, graduate capstone supervisor, and rotation supervisor for current genetic counseling students. She is actively engaged in the Fanconi anemia community and has been a volunteer at Fanconi Anemia Family Week since 2016, and she is a two-time nominee of the Heart of Genetic Counseling Award from the National Society of Genetic Counselors.

 

Key:

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Hereditary Gastrointestinal Cancer Syndromes, Polyposis
Open to view video.  |  38 minutes
Open to view video.  |  38 minutes Identify the features distinguishing different hereditary polyposis syndromes Recognize the association between polyp histology and potential germline genetic predisposition to a polyposis syndrome Discern the features of different polyposis syndromes, including: Familial adenomatous polyposis; MutYH-associated polyposis; Hamartomatous polyposis syndromes; Serrated polyposis syndrome
Hereditary Gastrointestinal Cancer Syndromes, Gastric Pancreatic
Open to view video.  |  52 minutes
Open to view video.  |  52 minutes Recognize features associated with hereditary risk for colorectal and other gastrointestinal cancers. Describe the genetic etiologies of hereditary gastrointestinal cancer syndromes. Explain the methods and limitations of tumor screening and germline genetic testing strategies.
Micro-learning: GCRA for a Patient with Colon Polyposis
Begin self-paced component package.
Begin self-paced component package.
ICSD 2026 - Bundle 7 Quiz
10 Questions  |  Unlimited attempts  |  10/12 points to pass
10 Questions  |  Unlimited attempts  |  10/12 points to pass Select the appropriate response for each question. Correct responses will display after a passing score of 80% (10/12) is reached. Please retake the quiz until you pass.
Bundle 7 Distance Learning Evaluation
9 Questions
9 Questions Please respond to the statements in this evaluation as they relate to your experiences with this week's distance learning modules. This survey will take less than 3 minutes to complete.