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Sonia S. Kupfer, MD

Sonia S. Kupfer, MD

Assistant Professor of Medicine

University of Chicago Medical Center

Sonia S. Kupfer is an Assistant Professor of Medicine in the Section of Gastroenterology at the University of Chicago Medical Center, Chicago, IL. She is the Director of the Gastrointestinal Cancer Risk and Prevention Clinic and co-Director of the Comprehensive Cancer Risk and Prevention clinic at the University of Chicago. She is funded by a K08 career development award from the NIH/NCI to study colorectal cancer genetic susceptibility variants in African Americans. Dr. Kupfer is also currently investigating genetics related to chemopreventive agents for colorectal cancer, notably vitamin D. In addition to her translational research, Dr. Kupfer is actively engaged in clinical studies in high-risk colorectal cancer primarily Lynch syndrome. Her clinical work focuses on hereditary GI cancer evaluation, testing and management. She also has served as co-Director of two CME conferences on genomics. Dr. Kupfer received her undergraduate degree from Yale University and then completed medical school, residency, chief residency and gastroenterology fellowship training at the University of Chicago. She is originally from a northern suburb of Chicago and currently resides in the Hyde Park area with her husband, an art dealer, and her two children.

Heather Hampel, MS, CGC

Heather Hampel, MS, CGC

Associate Director, Division of Clinical Cancer Genomics

City of Hope

Heather Hampel, MS, CGC is a Professor in the Department of Medical Oncology and Therapeutics Research and Associate Director of the Division of Cancer Genomics at City of Hope National Cancer Center. At City of Hope, she helps lead a team of 17 genetic counselors and 3 genetic counseling assistants and is actively involved in the Center for Precision Medicine INSPIRE study which provides universal germline genetic testing to all City of Hope patients. She has >200 publications on a variety of cancer genetics topics with an emphasis on Lynch syndrome. She was on the Board of Directors for the American Board of Genetic Counseling from 2006-2011 (President, 2009-10). She has been on the Steering Committee of the National Colorectal Cancer Roundtable since 2016. She was on the Council of the Collaborative Group of the Americas on Inherited Colorectal Cancer from 2016-2019 (President, 2017-2018). She was the Secretary/Treasurer of the National Society of Genetic Counselors in 2021-2022. In 2023, she received the Natalie Weissberger Paul National Achievement Award from the National Society of Genetic Counselors. In 2025, she received the Achievement Award from the Collaborative Group of the Americas for Inherited Gastrointestinal Cancers.

Lauren Gima, MS, CGC

Lauren Gima, MS, CGC

Senior Genetic Counselor

City of Hope

LAUREN GIMA, MS, CGC is a board-certified, licensed genetic counselor at City of Hope in Duarte, CA, where she specializes in clinical cancer genomics. She earned her MS degree in Genetic Counseling from Northwestern University and BS degree in Human Biology from University of California San Diego. Her primary clinical responsibilities include providing cancer genetic counseling services for City of Hope’s patient population and her primary research interest is in hereditary GI cancer syndromes. Ms. Gima is a faculty member of the City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice, and an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics masters’ programs. She serves as a clinical rotation supervisor for genetic counseling students and as a mentor for the KGI Genetic Counseling program, providing ongoing support and guidance for new genetic counseling students. Lauren is a member of the National Society of Genetic Counselors, the Collaborative Group of the Americas on Inherited Gastrointestinal Cancers, the Southern California Genetic Counselors, the Minority Genetics Professionals Network, and the Alliance for Genomic Justice.

Sandra Dreike, MS, CGC

Sandra Dreike, MS, CGC

Manager, Genetic Counselor

City of Hope

SANDRA DREIKE, MS, CGC is a licensed board-certified genetic counselor who specializes in cancer genetics. Sandra joined the City of Hope Division of Clinical Cancer Genomics in 2019, where she provides genetic counseling and cancer genetic risk assessments as a Senior Genetic Counselor. She received her Master of Science degree is Genetic Counseling from University of California, Irvine and her bachelor’s degree in Biology from California Polytechnic State University, San Luis Obispo. She previously practiced as a genetic counselor in Honolulu, HI where she specialized in cancer genetics and general pediatric and adult genetics. In addition to patient care she is a faculty member of the City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice, and research. Sandra is a member of the National Society of Genetic Counselors (NSGC) and Southern California Genetic Counselors (SCGC).

Key:

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Hereditary Gastrointestinal Cancer Syndromes, Lynch Syndrome
Open to view video.  |  43 minutes
Open to view video.  |  43 minutes Recognize the features of hereditary gastrointestinal and other cancers associated with Lynch Syndrome Discuss the methods and limitations of tumor screening for Lynch syndrome Identify the features and mode of inheritance of Constitutional Mismatch Repair Deficiency (CMMRD) Recognize the characteristics of Familial Colorectal Cancer Type X
Significance and Practical Applications for Tumor Phenotyping (IHC/MSI) in Hereditary Cancer Risk Assessment
Open to view video.  |  64 minutes
Open to view video.  |  64 minutes Review the mismatch repair (MMR) mechanism and the association of MMR deficiency in Lynch syndrome Recognize the importance of universal MSI/IHC tumor screening on newly diagnosed colorectal and endometrial cancers Review EGAPP recommendations Utilize MSI/IHC screening results for risk assessment in clinical cases Utilize MSI/IHC screening results for risk assessment in clinical cases
Micro-Learning: GCRA for a Patient with Colorectal Cancer
Begin self-paced component package.
Begin self-paced component package.
Micro-Learning: Mismatch Repair Deficiency
Begin self-paced component package.
Begin self-paced component package.
ICSD 2026 - Bundle 6 Quiz
8 Questions  |  Unlimited attempts  |  11/13 points to pass
8 Questions  |  Unlimited attempts  |  11/13 points to pass Select the appropriate response for each question. Correct responses will display after a passing score of 80% (11/13) is reached. Please retake the quiz until you pass.
Bundle 6 Distance Learning Evaluation
10 Questions
10 Questions Please respond to the statements in this evaluation as they relate to your experiences with this week's distance learning modules. This survey will take less than 3 minutes to complete.