Week 7 2023

Hereditary Gastrointestinal Cancer Syndromes, Polyposis

Objectives

  • Identify the features distinguishing different hereditary polyposis syndromes
  • Recognize the association between polyp histology and potential germline genetic predisposition to a polyposis syndrome
  • Discern the features of different polyposis syndromes, including: Familial adenomatous polyposis; MutYH-associated polyposis; Hamartomatous polyposis syndromes; Serrated polyposis syndrome

Hereditary Gastrointestinal Cancer Syndromes, Gastric Pancreatic

Objectives

  • Recognize the features of hereditary gastric cancers
  • Recognize the features of hereditary pancreatic cancers
  • Apply appropriate germline genetic testing strategies for hereditary gastrointestinal syndromes

Gregory Idos MD, MS

Associate Clinical Professor, Department of Medicine, Division of Gastroenterology

City of Hope

Dr. Idos is a board-certified gastroenterologist and trained cancer geneticist, who specializes in the care of patients with Lynch syndrome, FAP (familial adenomatous polyposis) and other inherited syndromes. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients.

A UCLA graduate, Dr. Idos has a master’s degree from Keck School of Medicine of USC. He received his medical degree at University of Vermont, continued his residency training at USC and completed his gastroenterology fellowship at Brigham and Women’s Hospital at Harvard. Dr. Idos is an associate clinical professor in Division of Gastroenterology and leads one of the largest multicenter studies examining the benefits and harms of “multiplex” gene panel testing. His research also focuses on the evaluation of novel technologies with the goal of providing new tools for hereditary cancer risk assessment and the development of novel cellular models to elucidate the fundamental mechanisms of microsatellite instability and Lynch syndrome.

Sonia S. Kupfer, MD

Assistant Professor of Medicine

University of Chicago Medical Center

Sonia S. Kupfer is an Assistant Professor of Medicine in the Section of Gastroenterology at the University of Chicago Medical Center, Chicago, IL. She is the Director of the Gastrointestinal Cancer Risk and Prevention Clinic and co-Director of the Comprehensive Cancer Risk and Prevention clinic at the University of Chicago. She is funded by a K08 career development award from the NIH/NCI to study colorectal cancer genetic susceptibility variants in African Americans. Dr. Kupfer is also currently investigating genetics related to chemopreventive agents for colorectal cancer, notably vitamin D. In addition to her translational research, Dr. Kupfer is actively engaged in clinical studies in high-risk colorectal cancer primarily Lynch syndrome. Her clinical work focuses on hereditary GI cancer evaluation, testing and management. She also has served as co-Director of two CME conferences on genomics. Dr. Kupfer received her undergraduate degree from Yale University and then completed medical school, residency, chief residency and gastroenterology fellowship training at the University of Chicago. She is originally from a northern suburb of Chicago and currently resides in the Hyde Park area with her husband, an art dealer, and her two children.

Lauren Gima, MS, LCGC

Genetic Counselor

City of Hope

Lauren Gima, MS, CGC is a board-certified, licensed genetic counselor at City of Hope in Duarte, CA where she specializes in clinical cancer genomics. She earned her MS degree in Genetic Counseling from Northwestern University and BS degree in Human Biology from University of California San Diego. Her primary clinical responsibilities include providing cancer genetic counseling services for City of Hope’s patient population. She is a clinical rotation supervisor for students of the Keck Graduate Institute (KGI) Genetic Counseling program, the University of California Irvine Genetic Counseling program, and the University of California Los Angeles Genetic Counseling program. She also serves as a community mentor for the KGI Genetic Counseling program, providing ongoing support and guidance for new genetic counseling students. Lauren is a member of the National Society of Genetic Counselors, the Collaborative Group of the Americas on Inherited Gastrointestinal Cancers, the Southern California Genetic Counselors, and the Minority Genetics Professionals Network.

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