Judy Garber, MD, MPH

Director, Center for Cancer Genetics and Prevention

Dana Farber Cancer Institute

Dr. Garber is the Director of the Cancer Genetics and Prevention Disease Center at Dana-Farber Cancer Institute and a Professor of Medicine at Harvard Medical School. Dr. Garber conducts research in clinical cancer genetics, with a special focus in the genetics of breast cancer. She has played a major role in the development of national guidelines in cancer genetics. She is also a leader in research into the characteristics and treatment of triple negative or basal-like breast cancer, the most common form in women with BRCA1 mutations. Her translational research focuses on the evaluation of novel agents targeting DNA repair defects in breast cancer, including PARP inhibitors for treatment and prevention of breast cancer and other BRCA-associated cancers.

 In 2011-2012, Dr. Garber was the President of American Association for Cancer Research (AACR), the largest organization of cancer researchers in the world. She is a member of the National Cancer Advisory Board and was recently elected to the Institute of Medicine.

Carol Fabian, MD

Director, Breast Cancer Prevention & Survivorship Centers

KU Breast Cancer Prevention Center

Dr. Carol Fabian is a breast medical oncologist, University Distinguished Professor, and holds the Morris Endowed Chair in Cancer Prevention at the University of Kansas Medical Center.  She received her medical degree from the University of Kansas in 1972, and fellowship in Medical Oncology at the University of Kansas in 1977.  She is board certified in both Internal Medicine and Medical Oncology.  She  has been on the faculty in the Division of Medical Oncology since 1977 and has served in multiple capacities including Medical Director of the Cancer Center, Founder and Director of the Breast Cancer Prevention and Survivorship Research Center, Leader or co-Leader of the Cancer Prevention Program, and Associate Director of Clinical Research in the NCI Designated Cancer Center.

Thomas Slavin, MD, FACMG, DABMD

Senior Vice President of Medical Affairs for Oncology

Myriad Genetics

Dr. Slavin is Senior Vice President of Medical Affairs for Oncology at Myriad Genetics. He is a physician-scientist, triple-board-certified in clinical genetics, molecular diagnostics and pediatrics. Most recently, he served as assistant professor in the departments of Medical Oncology & Therapeutics Research and Population Sciences at City of Hope National Medical Center. Dr. Slavin graduated medical school with Alpha-Omega-Alpha-honors from the University of South Florida. He completed his residency programs at Case Western Reserve in Cleveland, Ohio; this training included a postdoctoral research year in genetic epidemiology. He has also completed graduate course work towards a Masters degree in clinical research through the University of Southern California. He is an active member of the American Association of Cancer Research, the American Society of Clinical Oncology (ASCO), the American Society of Human Genetics, the Collaborative Group of the Americas on Inherited Colorectal Cancer, and is a fellow of the American College of Medical Genetics and Genomics. He has served on National Comprehensive Cancer Network (NCCN)committees for both the genetics of and screening for colorectal cancer. He has served on three ClinGen expert working group committees for variant classification of breast, gastrointestinal and ovarian cancer predisposition genes. Focused on expanding genetics education for cancer care providers, Dr. Slavin has helped shape both ASCO University as well as City of Hope’s hereditary genomics training program. He is a well-published researcher in the field of medical genetics, including over 60 journal articles, multiple book chapters, and numerous presentations at national and international medical meetings. He has been involved in many national cancer research grants, and was a 2018 National Institutes of Health (NIH) K08-career development grant awardee.

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Clinical Management of Hereditary Breast & Ovarian Cancers, Part 1
Open to view video.
Open to view video. Review NCCN guidelines for high-risk cancer screening and management Identify the methods and efficacy of breast and gynecologic screening tools Identify the methods and efficacy of breast and ovarian surgical risk reduction Understand the potential impact of cancer risk assessment and genetic testing related to surgical decision-making and timing Recognize emerging role of targeted therapies for high-risk individuals (e.g., BRCA, PTEN, etc.)
Clinical Management of Hereditary Breast & Ovarian Cancers, Part 2
Open to view video.
Open to view video. Review chemopreventive clinical trials pertinent to individuals at high risk for developing cancer Apply these data appropriately to individuals at genetic versus empiric high risk Describe chemoprevention studies currently open for enrollment
Other Genes on Panels: "Managing Moderate Penetrance"
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Open to view video. Describe the differences between a high, moderate, and low penetrance cancer susceptibility genes. Counsel a patient about moderate and low penetrance cancer susceptibility genes found on routine clinical testing. Identify that moderate and low penetrance cancer susceptibility genes may not track with the family history of cancer. Recognize that cancer susceptibility genes on clinical panels are not always actionable.
Quiz Week 5
4 Questions  |  Unlimited attempts  |  0/6 points to pass
4 Questions  |  Unlimited attempts  |  0/6 points to pass Quiz for review
Week 5 Distance Learning Evaluation
8 Questions
8 Questions Please respond to this evaluation as they relate to your experiences with this week's Distance Learning Modules and Friday Web Conference Review session. This survey will take less than 3 minutes to complete.
GCRA Case Conference Feedback Form
7 Questions
7 Questions Please respond to the statements below as they relate to your participation in this week’s LIVE or RECORDED GCRA Case Conference session. Complete this form within 24 hours after participating in the session. Reminder: 5 GCRA Case Conference Feedback forms must be submitted as a requirement to receive your Intensive Course Certificate.
Week 5 Friday Review Session Recording
Open to view video.
Open to view video.