
IC 2021
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Contains 1 Component(s)
Orientation and Pre-Course Assignments for IC 2021
Orientation and Pre-Course Assignments must be completed prior to Week 1 modules. 2021
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Contains 4 Component(s)
GCRA Case Assignment
The purpose of this assignment is to prepare and present a challenging or interesting case from your clinical practice. All IC participants must submit and present at least one case during the course.
Due Date: Starting Friday November 15, 2019
Within the form you will be instructed where to upload an ANONYMIZED copy of the patient pedigree and an ANONYMIZED copy of genetic test results. Please contact Kathleen Blazer at kblazer@coh.org if you have any questions about this assignment using the subject header: "IC Case Presentation Question".
Important: Please download and save a PDF of this assignment (including pedigree and attachments) for your records when you present this case.
If you need to exit before finishing, click the Save and Return button and WRITE DOWN the access code that pops up so that you can e-enter the survey and continue from where you left off.
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Contains 5 Component(s)
This is the module for the Post-case scenario
This is the module for the Post-case scenario.
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Contains 7 Component(s)
Week 1 of Intensive Course 2021
Ilana Solomon, ScM, MA, CGC
Manager, Precision Medicine Program, Genetic Counselor
City of Hope
Ilana Solomon, ScM, MA, is a Manager of the Precision Medicine Program and a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree Genetic Counseling from the Johns Hopkins/National Human Genome Research Institute. Ilana joined the City of Hope Division of Clinical Cancer Genomics in 2013, where she has provided cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer. Since 2019 she also manages and develops City of Hope’s Precision Medicine Program, with the goal of providing all City of Hope patients with genomic-driven care. She has research interests in healthcare communication and implementation, genetic literacy, and ELSI in genomics. She helped co-develop Helping Oncology Patients Explore (HOPE) Genomics: a patient-directed IT platform for cancer genome sequencing education and return of results. She is faculty for the City of Hope Intensive Course in Genetic Cancer Risk Assessment. She is an active member of the National Society of Genetic Counselors and Southern California Genetic Counselors.
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Susan Shehayeb, MS, CGC
Senior Genetic Counselor
City of Hope
SUSAN SHEHAYEB, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She has a Master’s of Science degree in genetic counseling from University of California Irvine. Previous to completing her master’s degree, Ms. Shehayeb earned her bachelor’s degree in molecular, cell and developmental biology from University of California Los Angeles. Ms. Shehayeb joined the City of Hope Division of Clinical Cancer Genomics in 2017, having previously undergone clinical training at City of Hope. She is fluent in Arabic and is in the process of achieving fluency in Spanish.
Ms. Shehayeb's clinical role has centered on widening patient access to genetic counseling and testing throughout the City of Hope clinical network and on genetics representation and expertise in the setting of gynecologic oncology. She co-leads the curriculum development for educational initiatives within the City of Hope Clinical Division of Cancer Genomics. Her research work and special interests focus on hereditary breast and ovarian cancers, hereditary genodermatoses, precision medicine in hereditary cancer care, and Justice, Equity, Diversity, and Inclusion (JEDI) in cancer genetics training. She is a member of the National Society of Genetic Counselors and the Southern California Genetic Counselors.
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Jeffrey Weitzel, MD
Professor of Oncology and Population Sciences
Jeffrey N. Weitzel, MD, is board Certified in Medical Oncology and Clinical Genetics, and founded the Clinical Cancer Genomics Community Research Network. He co-founded the Clinical Cancer Genomics Community of Practice with Dr. Blazer. A Breast Cancer Research Foundation Scholar and an honorary Professor of Oncology for the Latin American School of Oncology, he is also the ASCO Conquer Cancer Research Professor in Breast Cancer Disparities. At the vanguard of precision prevention, Dr. Weitzel’s multidisciplinary clinical, research, and training experience emphasize translational research in cancer disparities, genomic cancer risk assessment, chemoprevention, targeted therapy, clinical and psychosocial outcomes, genetic epidemiology and health services research, with a focus on underserved populations. Dr. Weitzel received the American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education.
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Week 2 of Intensive Course
Kathleen R. Blazer, EdD, MS, CGC
Clinical Assistant Professor, Director of Cancer Genomics Education Program
KATHLEEN R. BLAZER, EdD, MS, CGC, is Assistant Professor in the Department of Population Sciences and Director of the Cancer Genomics Education Program, a multifaceted cancer genetics education and training program for physicians, allied health care professionals and post-doctoral researchers, with the Division of Clinical Cancer Genomics at City of Hope National Medical Center. Dr. Blazer has played an integral role in the development, administration and assessment of the NCI-funded initiatives of the CGEP since joining the division in 1998. The outcomes and theoretical framework her education research serve as the cornerstone of the Intensive Course and Clinical Cancer Genomics Community of Practice (CCGCoP), which brings cancer genetics practitioners from diverse practice settings together for professional learning and enduring patient-centered support across the U.S. and internationally. She is recipient of the 2019 American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education, in recognition of the scope and reach of the education initiatives of the CGEP since its inception in 1997. She is a member of the American Society of Human Genetics, the National Society of Genetic Counselors, American Society of Clinical Oncology, the American Association of Cancer Education, and the National Human Genome Research Institute Inter-Society Coordinating Committee for Practitioner Education in Genomics.
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Charité Ricker, MS, CGC
Cancer Genetic Counselor and Genetic Services Coordinator
Charité Ricker, MS, LCGC - is a board certified genetic counselor with specialization in hereditary cancer risk assessment with the University of Southern California, Keck School of Medicine. She has a Bachelor’s of Science in genetics from Texas A&M University and received her Masters of Science in genetic counseling at California State University, Northridge. Ms. Ricker is fluent in Spanish and is interested in the provision of cancer genetics services in medically underserved and culturally diverse populations. She is actively involved in cancer genetics education to physicians, physician fellows, nurses, other healthcare professionals and patients. Ms. Ricker is a voting member of the Institutional Review Board for the USC Health Science Campus, LAC+USC Medical Center and Health Research Association. Ms. Ricker is a member of the National Society of Genetic Counselors (NSGC), the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA), the American Society of Clinical Oncology (ASCO), and the Society of Behavioral Medicine (SBM). She has served as the chair of the NSGC Cultural Competency Sub-committee and as a member of the ASCO Genetics Sub-committee. She was the 2019 recipient of the NSGC’s Leader in Cultural Advocacy Award.
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Bita Nehoray, MS, CGC
Manager, Genetic Counselor
City of Hope
Bita Nehoray, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree in Human Genetics and Genetic Counseling from Stanford University. Ms. Nehoray joined the City of Hope Division of Clinical Cancer Genomics in 2012, where she provides cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer, with a focus in Li-Fraumeni syndrome and clonal hematopoiesis of indeterminate potential. Current research projects include understanding cancer risk, penetrance, prevalence, and clinical outcomes for individuals with TP53 pathogenic variants as part of the LiFT UP study, evaluating the use of whole body MRI and liquid biopsy for early cancer detection, chatbot use for disclosure of germline genetic test results, and assessing community-based provider experiences with TP53 results on germline testing. She also serves on the genetic counseling advisory committee for the Li-Fraumeni Syndrome Association, the ClinGen TP53 Variant Curation Expert Panel, and the California Advisory Council for Sharsheret. She is faculty for the City of Hope Intensive Course in Genetic Cancer Risk Assessment. She is an active member of the National Society of Genetic Counselors and Southern California Genetic Counselors.
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Week 3 of Intensive Course
Colin Pritchard, MD, PhD
Assistant Professor
University of Washington
COLIN PRITCHARD, MD, PhD, is a Professor of Laboratory Medicine and Pathology at the University of Washington and Program Director for Cancer Precision Diagnostics for the Brotman Baty Institute for Precision Medicine. He also serves as the Co-Director of the Genetics and Solid Tumors Laboratory that services the Fred Hutchinson Cancer Center. The Pritchard laboratory focuses on oncology molecular diagnostics, particularly the source and utility of cell-free nucleic acid biomarkers in blood, and the development of innovative molecular diagnostics for the identification of DNA repair gene mutations that can guide therapeutic decision-making. His clinical work focuses on applications of next-generation sequencing gene panels for cancer risk assessment and precision treatment. He has led the development and implementation of the ColoSeq™ Lynch and Polyposis Syndrome Panel and the UW-OncoPlex™ Cancer Gene Panel in current clinical use for cancer patients and their families. He is a longstanding distinguished faculty member of the City of Hope Clinical Cancer Genomics Community of Practice. In 2021 Dr. Pritchard was awarded the C2 Catalyst for Precision Medicine Award from Scientific American.
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Danielle Castillo, BS
Senior Research Associate
Danielle Castillo, BS, is a Senior Research Associate in the Department of Clinical Cancer Genetics Molecular Laboratory at the City of Hope, where she assists Mr. Herzog in the maintenance of the Breast Cancer Registry, Hispanic Mutation Project, LiFTUP Project and other research endeavors. After spending a good part of her senior year working on water conservation at Stellenbosch University in Cape Town, South Africa Mrs. Castillo graduated with a bachelor’s degree in biology from Whittier College in 2008 Mrs. Castillo worked as a biologist for Irvine Scientific before coming to the City of Hope in early 2009.
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Week 4 of Intensive Course
Jeffrey Weitzel, MD
Professor of Oncology and Population Sciences
Jeffrey N. Weitzel, MD, is board Certified in Medical Oncology and Clinical Genetics, and founded the Clinical Cancer Genomics Community Research Network. He co-founded the Clinical Cancer Genomics Community of Practice with Dr. Blazer. A Breast Cancer Research Foundation Scholar and an honorary Professor of Oncology for the Latin American School of Oncology, he is also the ASCO Conquer Cancer Research Professor in Breast Cancer Disparities. At the vanguard of precision prevention, Dr. Weitzel’s multidisciplinary clinical, research, and training experience emphasize translational research in cancer disparities, genomic cancer risk assessment, chemoprevention, targeted therapy, clinical and psychosocial outcomes, genetic epidemiology and health services research, with a focus on underserved populations. Dr. Weitzel received the American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education.
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Julie Culver, MS, CGC
Director of Genetic Counseling, USC Norris Cancer Hospital | Clinical Instructor of Medicine, Division of Medical Oncology, Keck School of Medicine of USC
USC Norris Comprehensive Cancer Center
Julie Culver, MS, CGC, CCRP is Director of Cancer Genetic Counseling and Assistant Professor at the USC Norris Comprehensive Cancer Center. She received her Master’s degree at the University of Michigan in Ann Arbor in 1994. Ms. Culver then worked on research pertaining to breast cancer risk assessment and the public health impact of BRCA testing at the University of Washington and the Fred Hutchinson Cancer Research in Seattle for almost a decade. In 2004, she joined the City of Hope Division of Clinical Cancer Genetics where she worked for 8 years and served as the Assistant Director of the Cancer Screening & Prevention Program Network. She continued her research pertaining to hereditary breast and ovarian cancer and decision-making for woman carrying deleterious BRCA mutations and variants of uncertain significance. In 2012, she moved to the USC Norris Cancer Comprehensive Cancer Center where she currently serves on the faculty of Medical Oncology and is the lead genetic counselor. Her research pertains to high risk screening for breast cancer, cancer risk perception, and medical decision-making following genetic testing. She has served on the faculty for the City of Hope Intensive Course and taught cancer risk assessment to health professionals and students since 2004.
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Bita Nehoray, MS, CGC
Manager, Genetic Counselor
City of Hope
Bita Nehoray, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree in Human Genetics and Genetic Counseling from Stanford University. Ms. Nehoray joined the City of Hope Division of Clinical Cancer Genomics in 2012, where she provides cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer, with a focus in Li-Fraumeni syndrome and clonal hematopoiesis of indeterminate potential. Current research projects include understanding cancer risk, penetrance, prevalence, and clinical outcomes for individuals with TP53 pathogenic variants as part of the LiFT UP study, evaluating the use of whole body MRI and liquid biopsy for early cancer detection, chatbot use for disclosure of germline genetic test results, and assessing community-based provider experiences with TP53 results on germline testing. She also serves on the genetic counseling advisory committee for the Li-Fraumeni Syndrome Association, the ClinGen TP53 Variant Curation Expert Panel, and the California Advisory Council for Sharsheret. She is faculty for the City of Hope Intensive Course in Genetic Cancer Risk Assessment. She is an active member of the National Society of Genetic Counselors and Southern California Genetic Counselors.
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Rachelle Manookian, MS, CGC
Genetic Counselor
Children's Hospital of Los Angeles
RACHELLE MANOOKIAN, MS, CGC is a licensed and board-certified cancer genetic counselor specializing in pediatric oncology at Children’s Hospital Los Angeles (CHLA). She was previously with the Division of Clinical Cancer Genomics at City of Hope, and before that, a general genetic counselor at the West VA Medical Center. She brings her growing expertise in medical education to her role as an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics master’s programs. She serves as a faculty mentor, graduate capstone supervisor, and rotation supervisor for current genetic counseling students. She is actively engaged in the Fanconi anemia community and has been a volunteer at Fanconi Anemia Family Week since 2016, and she is a two-time nominee of the Heart of Genetic Counseling Award from the National Society of Genetic Counselors.
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Week 5 of Intensive Course
Judy Garber, MD, MPH
Director, Center for Cancer Genetics and Prevention
Dana Farber Cancer Institute
Dr. Garber is the Director of the Cancer Genetics and Prevention Disease Center at Dana-Farber Cancer Institute and a Professor of Medicine at Harvard Medical School. Dr. Garber conducts research in clinical cancer genetics, with a special focus in the genetics of breast cancer. She has played a major role in the development of national guidelines in cancer genetics. She is also a leader in research into the characteristics and treatment of triple negative or basal-like breast cancer, the most common form in women with BRCA1 mutations. Her translational research focuses on the evaluation of novel agents targeting DNA repair defects in breast cancer, including PARP inhibitors for treatment and prevention of breast cancer and other BRCA-associated cancers.
In 2011-2012, Dr. Garber was the President of American Association for Cancer Research (AACR), the largest organization of cancer researchers in the world. She is a member of the National Cancer Advisory Board and was recently elected to the Institute of Medicine.
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Carol Fabian, MD
Director, Breast Cancer Prevention & Survivorship Centers
KU Breast Cancer Prevention Center
Dr. Carol Fabian is a breast medical oncologist, University Distinguished Professor, and holds the Morris Endowed Chair in Cancer Prevention at the University of Kansas Medical Center. She received her medical degree from the University of Kansas in 1972, and fellowship in Medical Oncology at the University of Kansas in 1977. She is board certified in both Internal Medicine and Medical Oncology. She has been on the faculty in the Division of Medical Oncology since 1977 and has served in multiple capacities including Medical Director of the Cancer Center, Founder and Director of the Breast Cancer Prevention and Survivorship Research Center, Leader or co-Leader of the Cancer Prevention Program, and Associate Director of Clinical Research in the NCI Designated Cancer Center.
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Thomas Slavin, MD, FACMG, DABMD
Senior Vice President of Medical Affairs for Oncology
Myriad Genetics
Dr. Slavin is Senior Vice President of Medical Affairs for Oncology at Myriad Genetics. He is a physician-scientist, triple-board-certified in clinical genetics, molecular diagnostics and pediatrics. Most recently, he served as assistant professor in the departments of Medical Oncology & Therapeutics Research and Population Sciences at City of Hope National Medical Center. Dr. Slavin graduated medical school with Alpha-Omega-Alpha-honors from the University of South Florida. He completed his residency programs at Case Western Reserve in Cleveland, Ohio; this training included a postdoctoral research year in genetic epidemiology. He has also completed graduate course work towards a Masters degree in clinical research through the University of Southern California. He is an active member of the American Association of Cancer Research, the American Society of Clinical Oncology (ASCO), the American Society of Human Genetics, the Collaborative Group of the Americas on Inherited Colorectal Cancer, and is a fellow of the American College of Medical Genetics and Genomics. He has served on National Comprehensive Cancer Network (NCCN)committees for both the genetics of and screening for colorectal cancer. He has served on three ClinGen expert working group committees for variant classification of breast, gastrointestinal and ovarian cancer predisposition genes. Focused on expanding genetics education for cancer care providers, Dr. Slavin has helped shape both ASCO University as well as City of Hope’s hereditary genomics training program. He is a well-published researcher in the field of medical genetics, including over 60 journal articles, multiple book chapters, and numerous presentations at national and international medical meetings. He has been involved in many national cancer research grants, and was a 2018 National Institutes of Health (NIH) K08-career development grant awardee.
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Week 6 of Intensive Course
Sonia S. Kupfer, MD
Assistant Professor of Medicine
University of Chicago Medical Center
Sonia S. Kupfer is an Assistant Professor of Medicine in the Section of Gastroenterology at the University of Chicago Medical Center, Chicago, IL. She is the Director of the Gastrointestinal Cancer Risk and Prevention Clinic and co-Director of the Comprehensive Cancer Risk and Prevention clinic at the University of Chicago. She is funded by a K08 career development award from the NIH/NCI to study colorectal cancer genetic susceptibility variants in African Americans. Dr. Kupfer is also currently investigating genetics related to chemopreventive agents for colorectal cancer, notably vitamin D. In addition to her translational research, Dr. Kupfer is actively engaged in clinical studies in high-risk colorectal cancer primarily Lynch syndrome. Her clinical work focuses on hereditary GI cancer evaluation, testing and management. She also has served as co-Director of two CME conferences on genomics. Dr. Kupfer received her undergraduate degree from Yale University and then completed medical school, residency, chief residency and gastroenterology fellowship training at the University of Chicago. She is originally from a northern suburb of Chicago and currently resides in the Hyde Park area with her husband, an art dealer, and her two children.
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Gregory Idos MD, MS
Associate Clinical Professor, Department of Medicine, Division of Gastroenterology
City of Hope
Dr. Idos is a board-certified gastroenterologist and trained cancer geneticist, who specializes in the care of patients with Lynch syndrome, FAP (familial adenomatous polyposis) and other inherited syndromes. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients.
A UCLA graduate, Dr. Idos has a master’s degree from Keck School of Medicine of USC. He received his medical degree at University of Vermont, continued his residency training at USC and completed his gastroenterology fellowship at Brigham and Women’s Hospital at Harvard. Dr. Idos is an associate clinical professor in Division of Gastroenterology and leads one of the largest multicenter studies examining the benefits and harms of “multiplex” gene panel testing. His research also focuses on the evaluation of novel technologies with the goal of providing new tools for hereditary cancer risk assessment and the development of novel cellular models to elucidate the fundamental mechanisms of microsatellite instability and Lynch syndrome.
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Week 7 of Intensive Course
Heather Hampel, MS, CGC
Associate Director, Division of Clinical Cancer Genomics
City of Hope
HEATHER HAMPEL, MS, CGC, is a Professor in the Department of Medical Oncology and Therapeutics Research and Associate Director of the Division of Cancer Genomics at City of Hope National Cancer Center. She co-leads the administration of more than 20 genetic counselors, 6 GCAs, and additional support staff who provide genetic cancer risk assessment through the City of Hope enterprise and more than 20 CRAs, LVNs and CRNs on the Precision Medicine consent team. Her research focuses on Lynch syndrome and universal tumor screening for Lynch syndrome. She has >190 publications on the prevalence of Lynch syndrome among colorectal and endometrial cancer patients, the best testing protocols, cost-effectiveness, and referral guidelines for cancer genetics. She was on the Board of Directors for the American Board of Genetic Counseling from 2006-2011, serving as President in 2009 and 2010. She has been on the Steering Committee of the National Colorectal Cancer Roundtable since 2016. She was on the Council of the Collaborative Group of the Americas on Inherited Colorectal Cancer from 2016-2019, serving as president in 2017-2018. She served as the Secretary/Treasurer of the National Society of Genetic Counselors in 2022. She was awarded the Natalie Weissberger Paul National Achievement Award from the National Society of Genetic Counselors in 2023.
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Patrick Lynch, MD
Professor, Department of Gastroenterology, Hepatology, & Nutrition
The University of Texas MD Anderson Cancer Center
Dr. Patrick Lynch is a gastroenterologist and scientist with specific expertise in cancer risk for mismatch repair gene mutation carriers. He is a Professor of Medicine in the Department of Gastroenterology, Hepatology and Nutrition at UT-MD Anderson Cancer Center in Houston, Texas. Dr. Lynch received his Law degree and degree in Medicine from Creighton University. His internship and residency were at the University of Arkansas for Medical Sciences. He completed his Fellowship in Gastroenterology at Baylor College of Medicine in Houston, Texas. Dr. Lynch provides surveillance for patients and families with hereditary colorectal cancers, and is actively involved in the counseling and management of these patients and families. He has led or collaborated on multiple NIH- and industry-funded studies in hereditary colorectal cancers, including basic science, clinical, chemoprevention and behavioral studies. He is a member of Council for and past President of the International Society for Gastrointestinal Hereditary Tumors (INSIGHT) and is past President of the Collaborative Group of the Americas on Inherited Colorectal Cancer. He was recently awarded a grant under the UTMDACC “Moonshot” program for further development of a web-based registry for familial cancer families.
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Lauren Gima, MS, LCGC
Genetic Counselor
City of Hope
Lauren Gima, MS, CGC is a board-certified, licensed genetic counselor at City of Hope in Duarte, CA where she specializes in clinical cancer genomics. She earned her MS degree in Genetic Counseling from Northwestern University and BS degree in Human Biology from University of California San Diego. Her primary clinical responsibilities include providing cancer genetic counseling services for City of Hope’s patient population. She is a clinical rotation supervisor for students of the Keck Graduate Institute (KGI) Genetic Counseling program, the University of California Irvine Genetic Counseling program, and the University of California Los Angeles Genetic Counseling program. She also serves as a community mentor for the KGI Genetic Counseling program, providing ongoing support and guidance for new genetic counseling students. Lauren is a member of the National Society of Genetic Counselors, the Collaborative Group of the Americas on Inherited Gastrointestinal Cancers, the Southern California Genetic Counselors, and the Minority Genetics Professionals Network.
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Deanna Erwin, MS, CGC
Genetic Counselor
Deanna J. Erwin is a genetic counselor at Color Health. She previously was a clinical genetic counselor in the Adult Genetics Clinic at Baylor College of Medicine and at the City of Hope.
She has a M.S. in Genetic Counseling from the University of Michigan and a B.S. in Biology and Psychology from the University of Massachusetts Amherst.
She is an active member of the National Society of Genetic Counselors (NSGC), where she participates in multiple special interest groups (Health IT, Leadership and Management, and Cancer), and committees (Access and Service Delivery and the Research, Quality, and Outcomes). She has a special interest in underserved populations and increasing access to genetic services.
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Lauren Gima, MS, CGC
Senior Genetic Counselor
City of Hope
LAUREN GIMA, MS, CGC is a board-certified, licensed genetic counselor at City of Hope in Duarte, CA, where she specializes in clinical cancer genomics. She earned her MS degree in Genetic Counseling from Northwestern University and BS degree in Human Biology from University of California San Diego. Her primary clinical responsibilities include providing cancer genetic counseling services for City of Hope’s patient population and her primary research interest is in hereditary GI cancer syndromes. Ms. Gima is a faculty member of the City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice, and an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics masters’ programs. She serves as a clinical rotation supervisor for genetic counseling students and as a mentor for the KGI Genetic Counseling program, providing ongoing support and guidance for new genetic counseling students. Lauren is a member of the National Society of Genetic Counselors, the Collaborative Group of the Americas on Inherited Gastrointestinal Cancers, the Southern California Genetic Counselors, the Minority Genetics Professionals Network, and the Alliance for Genomic Justice.
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Contains 1 Component(s)
Orientation and Pre-Course Assignments for IC 2021
Orientation and Pre-Course Assignments must be completed prior to Week 1 modules. 2021
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Contains 4 Component(s)
GCRA Case Assignment
The purpose of this assignment is to prepare and present a challenging or interesting case from your clinical practice. All IC participants must submit and present at least one case during the course.
Due Date: Starting Friday November 15, 2019
Within the form you will be instructed where to upload an ANONYMIZED copy of the patient pedigree and an ANONYMIZED copy of genetic test results. Please contact Kathleen Blazer at kblazer@coh.org if you have any questions about this assignment using the subject header: "IC Case Presentation Question".
Important: Please download and save a PDF of this assignment (including pedigree and attachments) for your records when you present this case.
If you need to exit before finishing, click the Save and Return button and WRITE DOWN the access code that pops up so that you can e-enter the survey and continue from where you left off.
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Contains 5 Component(s)
This is the module for the Post-case scenario
This is the module for the Post-case scenario.
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Contains 7 Component(s)
Week 1 of Intensive Course 2021
Ilana Solomon, ScM, MA, CGC
Manager, Precision Medicine Program, Genetic Counselor
City of Hope
Ilana Solomon, ScM, MA, is a Manager of the Precision Medicine Program and a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree Genetic Counseling from the Johns Hopkins/National Human Genome Research Institute. Ilana joined the City of Hope Division of Clinical Cancer Genomics in 2013, where she has provided cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer. Since 2019 she also manages and develops City of Hope’s Precision Medicine Program, with the goal of providing all City of Hope patients with genomic-driven care. She has research interests in healthcare communication and implementation, genetic literacy, and ELSI in genomics. She helped co-develop Helping Oncology Patients Explore (HOPE) Genomics: a patient-directed IT platform for cancer genome sequencing education and return of results. She is faculty for the City of Hope Intensive Course in Genetic Cancer Risk Assessment. She is an active member of the National Society of Genetic Counselors and Southern California Genetic Counselors.
Susan Shehayeb, MS, CGC
Senior Genetic Counselor
City of Hope
SUSAN SHEHAYEB, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She has a Master’s of Science degree in genetic counseling from University of California Irvine. Previous to completing her master’s degree, Ms. Shehayeb earned her bachelor’s degree in molecular, cell and developmental biology from University of California Los Angeles. Ms. Shehayeb joined the City of Hope Division of Clinical Cancer Genomics in 2017, having previously undergone clinical training at City of Hope. She is fluent in Arabic and is in the process of achieving fluency in Spanish.
Ms. Shehayeb's clinical role has centered on widening patient access to genetic counseling and testing throughout the City of Hope clinical network and on genetics representation and expertise in the setting of gynecologic oncology. She co-leads the curriculum development for educational initiatives within the City of Hope Clinical Division of Cancer Genomics. Her research work and special interests focus on hereditary breast and ovarian cancers, hereditary genodermatoses, precision medicine in hereditary cancer care, and Justice, Equity, Diversity, and Inclusion (JEDI) in cancer genetics training. She is a member of the National Society of Genetic Counselors and the Southern California Genetic Counselors.
Jeffrey Weitzel, MD
Professor of Oncology and Population Sciences
Jeffrey N. Weitzel, MD, is board Certified in Medical Oncology and Clinical Genetics, and founded the Clinical Cancer Genomics Community Research Network. He co-founded the Clinical Cancer Genomics Community of Practice with Dr. Blazer. A Breast Cancer Research Foundation Scholar and an honorary Professor of Oncology for the Latin American School of Oncology, he is also the ASCO Conquer Cancer Research Professor in Breast Cancer Disparities. At the vanguard of precision prevention, Dr. Weitzel’s multidisciplinary clinical, research, and training experience emphasize translational research in cancer disparities, genomic cancer risk assessment, chemoprevention, targeted therapy, clinical and psychosocial outcomes, genetic epidemiology and health services research, with a focus on underserved populations. Dr. Weitzel received the American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education.
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Contains 7 Component(s)
Week 2 of Intensive Course
Kathleen R. Blazer, EdD, MS, CGC
Clinical Assistant Professor, Director of Cancer Genomics Education Program
KATHLEEN R. BLAZER, EdD, MS, CGC, is Assistant Professor in the Department of Population Sciences and Director of the Cancer Genomics Education Program, a multifaceted cancer genetics education and training program for physicians, allied health care professionals and post-doctoral researchers, with the Division of Clinical Cancer Genomics at City of Hope National Medical Center. Dr. Blazer has played an integral role in the development, administration and assessment of the NCI-funded initiatives of the CGEP since joining the division in 1998. The outcomes and theoretical framework her education research serve as the cornerstone of the Intensive Course and Clinical Cancer Genomics Community of Practice (CCGCoP), which brings cancer genetics practitioners from diverse practice settings together for professional learning and enduring patient-centered support across the U.S. and internationally. She is recipient of the 2019 American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education, in recognition of the scope and reach of the education initiatives of the CGEP since its inception in 1997. She is a member of the American Society of Human Genetics, the National Society of Genetic Counselors, American Society of Clinical Oncology, the American Association of Cancer Education, and the National Human Genome Research Institute Inter-Society Coordinating Committee for Practitioner Education in Genomics.
Charité Ricker, MS, CGC
Cancer Genetic Counselor and Genetic Services Coordinator
Charité Ricker, MS, LCGC - is a board certified genetic counselor with specialization in hereditary cancer risk assessment with the University of Southern California, Keck School of Medicine. She has a Bachelor’s of Science in genetics from Texas A&M University and received her Masters of Science in genetic counseling at California State University, Northridge. Ms. Ricker is fluent in Spanish and is interested in the provision of cancer genetics services in medically underserved and culturally diverse populations. She is actively involved in cancer genetics education to physicians, physician fellows, nurses, other healthcare professionals and patients. Ms. Ricker is a voting member of the Institutional Review Board for the USC Health Science Campus, LAC+USC Medical Center and Health Research Association. Ms. Ricker is a member of the National Society of Genetic Counselors (NSGC), the Collaborative Group of the Americas on Inherited Colorectal Cancer (CGA), the American Society of Clinical Oncology (ASCO), and the Society of Behavioral Medicine (SBM). She has served as the chair of the NSGC Cultural Competency Sub-committee and as a member of the ASCO Genetics Sub-committee. She was the 2019 recipient of the NSGC’s Leader in Cultural Advocacy Award.
Bita Nehoray, MS, CGC
Manager, Genetic Counselor
City of Hope
Bita Nehoray, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree in Human Genetics and Genetic Counseling from Stanford University. Ms. Nehoray joined the City of Hope Division of Clinical Cancer Genomics in 2012, where she provides cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer, with a focus in Li-Fraumeni syndrome and clonal hematopoiesis of indeterminate potential. Current research projects include understanding cancer risk, penetrance, prevalence, and clinical outcomes for individuals with TP53 pathogenic variants as part of the LiFT UP study, evaluating the use of whole body MRI and liquid biopsy for early cancer detection, chatbot use for disclosure of germline genetic test results, and assessing community-based provider experiences with TP53 results on germline testing. She also serves on the genetic counseling advisory committee for the Li-Fraumeni Syndrome Association, the ClinGen TP53 Variant Curation Expert Panel, and the California Advisory Council for Sharsheret. She is faculty for the City of Hope Intensive Course in Genetic Cancer Risk Assessment. She is an active member of the National Society of Genetic Counselors and Southern California Genetic Counselors.
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Contains 9 Component(s)
Week 3 of Intensive Course
Colin Pritchard, MD, PhD
Assistant Professor
University of Washington
COLIN PRITCHARD, MD, PhD, is a Professor of Laboratory Medicine and Pathology at the University of Washington and Program Director for Cancer Precision Diagnostics for the Brotman Baty Institute for Precision Medicine. He also serves as the Co-Director of the Genetics and Solid Tumors Laboratory that services the Fred Hutchinson Cancer Center. The Pritchard laboratory focuses on oncology molecular diagnostics, particularly the source and utility of cell-free nucleic acid biomarkers in blood, and the development of innovative molecular diagnostics for the identification of DNA repair gene mutations that can guide therapeutic decision-making. His clinical work focuses on applications of next-generation sequencing gene panels for cancer risk assessment and precision treatment. He has led the development and implementation of the ColoSeq™ Lynch and Polyposis Syndrome Panel and the UW-OncoPlex™ Cancer Gene Panel in current clinical use for cancer patients and their families. He is a longstanding distinguished faculty member of the City of Hope Clinical Cancer Genomics Community of Practice. In 2021 Dr. Pritchard was awarded the C2 Catalyst for Precision Medicine Award from Scientific American.
Danielle Castillo, BS
Senior Research Associate
Danielle Castillo, BS, is a Senior Research Associate in the Department of Clinical Cancer Genetics Molecular Laboratory at the City of Hope, where she assists Mr. Herzog in the maintenance of the Breast Cancer Registry, Hispanic Mutation Project, LiFTUP Project and other research endeavors. After spending a good part of her senior year working on water conservation at Stellenbosch University in Cape Town, South Africa Mrs. Castillo graduated with a bachelor’s degree in biology from Whittier College in 2008 Mrs. Castillo worked as a biologist for Irvine Scientific before coming to the City of Hope in early 2009.
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Contains 10 Component(s)
Week 4 of Intensive Course
Jeffrey Weitzel, MD
Professor of Oncology and Population Sciences
Jeffrey N. Weitzel, MD, is board Certified in Medical Oncology and Clinical Genetics, and founded the Clinical Cancer Genomics Community Research Network. He co-founded the Clinical Cancer Genomics Community of Practice with Dr. Blazer. A Breast Cancer Research Foundation Scholar and an honorary Professor of Oncology for the Latin American School of Oncology, he is also the ASCO Conquer Cancer Research Professor in Breast Cancer Disparities. At the vanguard of precision prevention, Dr. Weitzel’s multidisciplinary clinical, research, and training experience emphasize translational research in cancer disparities, genomic cancer risk assessment, chemoprevention, targeted therapy, clinical and psychosocial outcomes, genetic epidemiology and health services research, with a focus on underserved populations. Dr. Weitzel received the American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education.
Julie Culver, MS, CGC
Director of Genetic Counseling, USC Norris Cancer Hospital | Clinical Instructor of Medicine, Division of Medical Oncology, Keck School of Medicine of USC
USC Norris Comprehensive Cancer Center
Julie Culver, MS, CGC, CCRP is Director of Cancer Genetic Counseling and Assistant Professor at the USC Norris Comprehensive Cancer Center. She received her Master’s degree at the University of Michigan in Ann Arbor in 1994. Ms. Culver then worked on research pertaining to breast cancer risk assessment and the public health impact of BRCA testing at the University of Washington and the Fred Hutchinson Cancer Research in Seattle for almost a decade. In 2004, she joined the City of Hope Division of Clinical Cancer Genetics where she worked for 8 years and served as the Assistant Director of the Cancer Screening & Prevention Program Network. She continued her research pertaining to hereditary breast and ovarian cancer and decision-making for woman carrying deleterious BRCA mutations and variants of uncertain significance. In 2012, she moved to the USC Norris Cancer Comprehensive Cancer Center where she currently serves on the faculty of Medical Oncology and is the lead genetic counselor. Her research pertains to high risk screening for breast cancer, cancer risk perception, and medical decision-making following genetic testing. She has served on the faculty for the City of Hope Intensive Course and taught cancer risk assessment to health professionals and students since 2004.
Bita Nehoray, MS, CGC
Manager, Genetic Counselor
City of Hope
Bita Nehoray, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree in Human Genetics and Genetic Counseling from Stanford University. Ms. Nehoray joined the City of Hope Division of Clinical Cancer Genomics in 2012, where she provides cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer, with a focus in Li-Fraumeni syndrome and clonal hematopoiesis of indeterminate potential. Current research projects include understanding cancer risk, penetrance, prevalence, and clinical outcomes for individuals with TP53 pathogenic variants as part of the LiFT UP study, evaluating the use of whole body MRI and liquid biopsy for early cancer detection, chatbot use for disclosure of germline genetic test results, and assessing community-based provider experiences with TP53 results on germline testing. She also serves on the genetic counseling advisory committee for the Li-Fraumeni Syndrome Association, the ClinGen TP53 Variant Curation Expert Panel, and the California Advisory Council for Sharsheret. She is faculty for the City of Hope Intensive Course in Genetic Cancer Risk Assessment. She is an active member of the National Society of Genetic Counselors and Southern California Genetic Counselors.
Rachelle Manookian, MS, CGC
Genetic Counselor
Children's Hospital of Los Angeles
RACHELLE MANOOKIAN, MS, CGC is a licensed and board-certified cancer genetic counselor specializing in pediatric oncology at Children’s Hospital Los Angeles (CHLA). She was previously with the Division of Clinical Cancer Genomics at City of Hope, and before that, a general genetic counselor at the West VA Medical Center. She brings her growing expertise in medical education to her role as an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics master’s programs. She serves as a faculty mentor, graduate capstone supervisor, and rotation supervisor for current genetic counseling students. She is actively engaged in the Fanconi anemia community and has been a volunteer at Fanconi Anemia Family Week since 2016, and she is a two-time nominee of the Heart of Genetic Counseling Award from the National Society of Genetic Counselors.
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Contains 7 Component(s)
Week 5 of Intensive Course
Judy Garber, MD, MPH
Director, Center for Cancer Genetics and Prevention
Dana Farber Cancer Institute
Dr. Garber is the Director of the Cancer Genetics and Prevention Disease Center at Dana-Farber Cancer Institute and a Professor of Medicine at Harvard Medical School. Dr. Garber conducts research in clinical cancer genetics, with a special focus in the genetics of breast cancer. She has played a major role in the development of national guidelines in cancer genetics. She is also a leader in research into the characteristics and treatment of triple negative or basal-like breast cancer, the most common form in women with BRCA1 mutations. Her translational research focuses on the evaluation of novel agents targeting DNA repair defects in breast cancer, including PARP inhibitors for treatment and prevention of breast cancer and other BRCA-associated cancers.
In 2011-2012, Dr. Garber was the President of American Association for Cancer Research (AACR), the largest organization of cancer researchers in the world. She is a member of the National Cancer Advisory Board and was recently elected to the Institute of Medicine.
Carol Fabian, MD
Director, Breast Cancer Prevention & Survivorship Centers
KU Breast Cancer Prevention Center
Dr. Carol Fabian is a breast medical oncologist, University Distinguished Professor, and holds the Morris Endowed Chair in Cancer Prevention at the University of Kansas Medical Center. She received her medical degree from the University of Kansas in 1972, and fellowship in Medical Oncology at the University of Kansas in 1977. She is board certified in both Internal Medicine and Medical Oncology. She has been on the faculty in the Division of Medical Oncology since 1977 and has served in multiple capacities including Medical Director of the Cancer Center, Founder and Director of the Breast Cancer Prevention and Survivorship Research Center, Leader or co-Leader of the Cancer Prevention Program, and Associate Director of Clinical Research in the NCI Designated Cancer Center.
Thomas Slavin, MD, FACMG, DABMD
Senior Vice President of Medical Affairs for Oncology
Myriad Genetics
Dr. Slavin is Senior Vice President of Medical Affairs for Oncology at Myriad Genetics. He is a physician-scientist, triple-board-certified in clinical genetics, molecular diagnostics and pediatrics. Most recently, he served as assistant professor in the departments of Medical Oncology & Therapeutics Research and Population Sciences at City of Hope National Medical Center. Dr. Slavin graduated medical school with Alpha-Omega-Alpha-honors from the University of South Florida. He completed his residency programs at Case Western Reserve in Cleveland, Ohio; this training included a postdoctoral research year in genetic epidemiology. He has also completed graduate course work towards a Masters degree in clinical research through the University of Southern California. He is an active member of the American Association of Cancer Research, the American Society of Clinical Oncology (ASCO), the American Society of Human Genetics, the Collaborative Group of the Americas on Inherited Colorectal Cancer, and is a fellow of the American College of Medical Genetics and Genomics. He has served on National Comprehensive Cancer Network (NCCN)committees for both the genetics of and screening for colorectal cancer. He has served on three ClinGen expert working group committees for variant classification of breast, gastrointestinal and ovarian cancer predisposition genes. Focused on expanding genetics education for cancer care providers, Dr. Slavin has helped shape both ASCO University as well as City of Hope’s hereditary genomics training program. He is a well-published researcher in the field of medical genetics, including over 60 journal articles, multiple book chapters, and numerous presentations at national and international medical meetings. He has been involved in many national cancer research grants, and was a 2018 National Institutes of Health (NIH) K08-career development grant awardee.
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Contains 7 Component(s)
Week 6 of Intensive Course
Sonia S. Kupfer, MD
Assistant Professor of Medicine
University of Chicago Medical Center
Sonia S. Kupfer is an Assistant Professor of Medicine in the Section of Gastroenterology at the University of Chicago Medical Center, Chicago, IL. She is the Director of the Gastrointestinal Cancer Risk and Prevention Clinic and co-Director of the Comprehensive Cancer Risk and Prevention clinic at the University of Chicago. She is funded by a K08 career development award from the NIH/NCI to study colorectal cancer genetic susceptibility variants in African Americans. Dr. Kupfer is also currently investigating genetics related to chemopreventive agents for colorectal cancer, notably vitamin D. In addition to her translational research, Dr. Kupfer is actively engaged in clinical studies in high-risk colorectal cancer primarily Lynch syndrome. Her clinical work focuses on hereditary GI cancer evaluation, testing and management. She also has served as co-Director of two CME conferences on genomics. Dr. Kupfer received her undergraduate degree from Yale University and then completed medical school, residency, chief residency and gastroenterology fellowship training at the University of Chicago. She is originally from a northern suburb of Chicago and currently resides in the Hyde Park area with her husband, an art dealer, and her two children.
Gregory Idos MD, MS
Associate Clinical Professor, Department of Medicine, Division of Gastroenterology
City of Hope
Dr. Idos is a board-certified gastroenterologist and trained cancer geneticist, who specializes in the care of patients with Lynch syndrome, FAP (familial adenomatous polyposis) and other inherited syndromes. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients.
A UCLA graduate, Dr. Idos has a master’s degree from Keck School of Medicine of USC. He received his medical degree at University of Vermont, continued his residency training at USC and completed his gastroenterology fellowship at Brigham and Women’s Hospital at Harvard. Dr. Idos is an associate clinical professor in Division of Gastroenterology and leads one of the largest multicenter studies examining the benefits and harms of “multiplex” gene panel testing. His research also focuses on the evaluation of novel technologies with the goal of providing new tools for hereditary cancer risk assessment and the development of novel cellular models to elucidate the fundamental mechanisms of microsatellite instability and Lynch syndrome. -
Contains 8 Component(s)
Week 7 of Intensive Course
Heather Hampel, MS, CGC
Associate Director, Division of Clinical Cancer Genomics
City of Hope
HEATHER HAMPEL, MS, CGC, is a Professor in the Department of Medical Oncology and Therapeutics Research and Associate Director of the Division of Cancer Genomics at City of Hope National Cancer Center. She co-leads the administration of more than 20 genetic counselors, 6 GCAs, and additional support staff who provide genetic cancer risk assessment through the City of Hope enterprise and more than 20 CRAs, LVNs and CRNs on the Precision Medicine consent team. Her research focuses on Lynch syndrome and universal tumor screening for Lynch syndrome. She has >190 publications on the prevalence of Lynch syndrome among colorectal and endometrial cancer patients, the best testing protocols, cost-effectiveness, and referral guidelines for cancer genetics. She was on the Board of Directors for the American Board of Genetic Counseling from 2006-2011, serving as President in 2009 and 2010. She has been on the Steering Committee of the National Colorectal Cancer Roundtable since 2016. She was on the Council of the Collaborative Group of the Americas on Inherited Colorectal Cancer from 2016-2019, serving as president in 2017-2018. She served as the Secretary/Treasurer of the National Society of Genetic Counselors in 2022. She was awarded the Natalie Weissberger Paul National Achievement Award from the National Society of Genetic Counselors in 2023.
Patrick Lynch, MD
Professor, Department of Gastroenterology, Hepatology, & Nutrition
The University of Texas MD Anderson Cancer Center
Dr. Patrick Lynch is a gastroenterologist and scientist with specific expertise in cancer risk for mismatch repair gene mutation carriers. He is a Professor of Medicine in the Department of Gastroenterology, Hepatology and Nutrition at UT-MD Anderson Cancer Center in Houston, Texas. Dr. Lynch received his Law degree and degree in Medicine from Creighton University. His internship and residency were at the University of Arkansas for Medical Sciences. He completed his Fellowship in Gastroenterology at Baylor College of Medicine in Houston, Texas. Dr. Lynch provides surveillance for patients and families with hereditary colorectal cancers, and is actively involved in the counseling and management of these patients and families. He has led or collaborated on multiple NIH- and industry-funded studies in hereditary colorectal cancers, including basic science, clinical, chemoprevention and behavioral studies. He is a member of Council for and past President of the International Society for Gastrointestinal Hereditary Tumors (INSIGHT) and is past President of the Collaborative Group of the Americas on Inherited Colorectal Cancer. He was recently awarded a grant under the UTMDACC “Moonshot” program for further development of a web-based registry for familial cancer families.
Lauren Gima, MS, LCGC
Genetic Counselor
City of Hope
Lauren Gima, MS, CGC is a board-certified, licensed genetic counselor at City of Hope in Duarte, CA where she specializes in clinical cancer genomics. She earned her MS degree in Genetic Counseling from Northwestern University and BS degree in Human Biology from University of California San Diego. Her primary clinical responsibilities include providing cancer genetic counseling services for City of Hope’s patient population. She is a clinical rotation supervisor for students of the Keck Graduate Institute (KGI) Genetic Counseling program, the University of California Irvine Genetic Counseling program, and the University of California Los Angeles Genetic Counseling program. She also serves as a community mentor for the KGI Genetic Counseling program, providing ongoing support and guidance for new genetic counseling students. Lauren is a member of the National Society of Genetic Counselors, the Collaborative Group of the Americas on Inherited Gastrointestinal Cancers, the Southern California Genetic Counselors, and the Minority Genetics Professionals Network.
Deanna Erwin, MS, CGC
Genetic Counselor
Deanna J. Erwin is a genetic counselor at Color Health. She previously was a clinical genetic counselor in the Adult Genetics Clinic at Baylor College of Medicine and at the City of Hope.
She has a M.S. in Genetic Counseling from the University of Michigan and a B.S. in Biology and Psychology from the University of Massachusetts Amherst.
She is an active member of the National Society of Genetic Counselors (NSGC), where she participates in multiple special interest groups (Health IT, Leadership and Management, and Cancer), and committees (Access and Service Delivery and the Research, Quality, and Outcomes). She has a special interest in underserved populations and increasing access to genetic services.Lauren Gima, MS, CGC
Senior Genetic Counselor
City of Hope
LAUREN GIMA, MS, CGC is a board-certified, licensed genetic counselor at City of Hope in Duarte, CA, where she specializes in clinical cancer genomics. She earned her MS degree in Genetic Counseling from Northwestern University and BS degree in Human Biology from University of California San Diego. Her primary clinical responsibilities include providing cancer genetic counseling services for City of Hope’s patient population and her primary research interest is in hereditary GI cancer syndromes. Ms. Gima is a faculty member of the City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice, and an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics masters’ programs. She serves as a clinical rotation supervisor for genetic counseling students and as a mentor for the KGI Genetic Counseling program, providing ongoing support and guidance for new genetic counseling students. Lauren is a member of the National Society of Genetic Counselors, the Collaborative Group of the Americas on Inherited Gastrointestinal Cancers, the Southern California Genetic Counselors, the Minority Genetics Professionals Network, and the Alliance for Genomic Justice.