Review Bundle 01

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Instruction
3 Learning Modules

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Time
2.25 Hours

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Tasks
3 Quizzes


Basic Genetics Primer, Part 1

  • Define the basic principles of gene structure, function, and regulation.
  • Appreciate the nature and consequences of major types of gene mutations.

Basic Genetics Primer, Part 2

  • Outline the principles of Mendelian inheritance.
  • Identify the features of incomplete penetrance and variable expressivity.
  • Recognize how genetic mechanisms such as de novo mutations, mosaicism and imprinting can affect the pattern of cancer in a family.

The Basic Science of Cancer Genetics

  • Distinguish the differences between somatic and germline mutations.
  • Describe the roles of oncogenes and tumor suppressor genes in signal transduction and cell cycle control.
  • Review the mechanisms of DNA damage

The modules in this bundle will discuss possible barriers and biases which may impact patient care (i.e., race, ethnicity, language, gender identity/orientation, age, socioeconomic status, attitudes, feelings, or other characteristics).


Accreditation Details for Bundle 1:

TARGET AUDIENCE: Physicians, Physician Assistants, Genetic Counselors, Master's or PhD in Genetics or Advanced Practice Nurses, and Geneticists.

ACCREDITATION STATEMENT: City of Hope is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION: City of Hope designates this enduring material for a maximum of 2.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

The following credit type(s) are being offered for this course:

 • AMA PRA Category 1 Credit™ 2.25

The following may apply AMA PRA Category 1 Credit™ for license renewal:

Registered Nurses: Nurses may report up to 2.25 credit hours toward the continuing education requirements for license renewal by their state Board of Registered Nurses (BRN). AMA PRA Category 1 Credit™ may be noted on the license renewal application in lieu of a BRN provider number.

Physician Assistants: The National Commission on Certification of Physicians Assistants states that AMA PRA Category 1 Credit™ accredited courses are acceptable for CME requirements for recertification.

Lauren Gima, MS, CGC

Senior Genetic Counselor

City of Hope

LAUREN GIMA, MS, CGC is a board-certified, licensed genetic counselor at City of Hope in Duarte, CA, where she specializes in clinical cancer genomics. She earned her MS degree in Genetic Counseling from Northwestern University and BS degree in Human Biology from University of California San Diego. Her primary clinical responsibilities include providing cancer genetic counseling services for City of Hope’s patient population. Ms. Gima is also a faculty member of the City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice, and an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics masters’ programs. She is also a clinical rotation supervisor for students of the Keck Graduate Institute (KGI) Genetic Counseling program, the University of California Irvine Genetic Counseling program, and the University of California Los Angeles Genetic Counseling program, and she serves as a community mentor for the KGI Genetic Counseling program, providing ongoing support and guidance for new genetic counseling students. Lauren is a member of the National Society of Genetic Counselors, the Collaborative Group of the Americas on Inherited Gastrointestinal Cancers, the Southern California Genetic Counselors, and the Minority Genetics Professionals Network.

Susan Shehayeb, MS, CGC

Senior Genetic Counselor

City of Hope

SUSAN SHEHAYEB, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics with the Division of Clinical Cancer Genomics at City of Hope National Medical Center. She is fluent in Arabic and has competency in Spanish. She has a Master of Science degree in genetic counseling from University of California Irvine. Ms. Shehayeb's clinical role has centered on widening patient access to genetic counseling and testing throughout the City of Hope network and on genetics representation and expertise in the setting of gynecologic oncology. Her past research has focused on lifestyle choices in the context of hereditary cancer testing, hereditary causes of multiple breast cancers, and hereditary gynecologic cancers. Her special interests include hereditary gynecologic cancers and hereditary genodermatoses, furthering education of providers in the setting of genomic cancer risk assessment, and advocacy for diversity and equity in the field of cancer genetics. She is a faculty member of the City of Hope Intensive Course in Genetic Cancer Risk Assessment, and a member of the National Society of Genetic Counselors and the Southern California Genetic Counselors.

Rachelle Manookian, MS, CGC

Genetic Counselor

Children's Hospital of Los Angeles

RACHELLE MANOOKIAN, MS, CGC is a licensed and board-certified cancer genetic counselor specializing in pediatric oncology at Children’s Hospital Los Angeles (CHLA). She was previously with the Division of Clinical Cancer Genomics at City of Hope, and before that, a general genetic counselor at the VA Medical Center serving six VA hospitals via telehealth. She has a special interest in genitourinary cancers. She brings her growing expertise in medical education to her role as an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics master’s programs. She serves as a faculty mentor, graduate capstone supervisor, and rotation supervisor for current genetic counseling students. She is actively engaged in the Fanconi anemia community and has been a volunteer at Camp Sunshine Fanconi Anemia week since 2016, and she is a two-time nominee of the Heart of Genetic Counseling Award from the National Society of Genetic Counselors

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