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All conference attendees are pre-registered for pre-paid access to the conference recordings. All others register below to the best of the 8th Annual Clinical Cancer Genomics Conference - From Exceptionalism to Exceptional Care: Mainstreaming Genomic Medicine In Clinical Practice
8th Annual Clinical Cancer Genomics Conference - From Exceptionalism to Exceptional Care: Mainstreaming Genomic Medicine In Clinical Practice
Rapid advances in next generation sequencing (NGS) technologies and market forces are driving a surge in demand for Genomic Cancer Risk Assessment (GCRA) services across the nation. Clinicians must be adequately prepared with the knowledge and skills needed to address the complexities associated with multigene panel testing, polygenic risk scores (PRS), and approaches that combine tumor and germline genomic profiles. This two-day conference brings a roster of nationally recognized speakers together with community-based clinicians from across the U.S. and personalized cancer risk assessment, treatment and preventive care.
- At the conclusion of this activity attendees will be able to:
- Identify the benefits and limitations of applying NGS information into cancer genetic/genomic risk assessment
- Examine the challenges related to broad genomic analyses, such as panels or exomes, that yield incidental findings
- Discuss the clinical utility of polygenic risk scores in cancer risk assessment
- Apply evidence-based cancer screening and prevention recommendations to clinical cases with pathogenic variants in moderate risk genes
- Discern the significance of germline findings in somatic tumor testing
- Recognize the importance of clinical-research collaborations to characterize lesser-known cancer risk genes
Antonis Antonious, PhD
Professor of Cancer Risk Prediction Academic Course Director MPhil Epidemiology
Antonis Antoniou, PhD is the Professor of Cancer Risk Prediction in the Department of Public Health and Primary Care, and Academic Course Director for the MPhil in Epidemiology at the University of Cambridge. He studied at the London School of Economics and Political Science and the University of Cambridge before gaining his PhD in Genetic Epidemiology at Cambridge in 2001Professor Antoniou’s primary research focus is the development and application of statistical modelling techniques for addressing clinical questions, and the development of risk prediction tools that are used in clinical practice. His research focuses on two broad areas: (1) The development and evaluation of risk prediction models for familial breast, ovarian, prostate and other common cancers; and (2) The characterization of cancer risks for genetically susceptible individuals, such as those carrying mutations in the BRCA1, BRCA2, PALB2, RAD51Cand RAD51D genes. Dr. Antoniou is a leader in the development and evolution of Boadicea, a comprehensive model designed to enable personalized breast cancer risk stratification and informed decision-making on prevention therapies and screening in the general population and in women with family history.
Leslie G. Biesecker, MD
Chief & Senior Investigator
Leslie Biesecker, MD, Is a clinical and molecular geneticist and Chief of the Medical Genomics and Metabolic Genetics Branch at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health. He received his medical training at the University of Illinois, training in pediatrics at the University of Wisconsin, and in clinical and molecular genetics at the University of Michigan. Dr. Biesecker’s research focuses on rare disorders of development and growth, and to new approaches to clinical genomics. His laboratory has elucidated the etiology and natural history of numerous diseases, including Proteus syndrome, PIK3CA-related overgrowth syndrome, TARP syndrome, oculofaciocardiodental syndrome, Lenz microphthalmia syndrome, McKusick-Kaufman syndrome, Bardet-Biedl syndrome, Pallister-Hall syndrome and Amish microcephaly, and has contributed to the discovery of many others. Dr. Biesecker is Principle Investigator of the ClinSeq® program, which to date has consented more than 1,000 subjects to participate in whole-genome sequencing, the mission of which is to develop new approaches to analyze and store genomic data, and to identify the best ways to share genetic information with participants and families.
Kathleen R. Blazer, EdD, MS, CGC
Clinical Assistant Professor, Director of Cancer Genomics Education Program
Kathleen R. Blazer is a Clinical Assistant Professor in the Department of Population Sciences, Director of the Cancer Genomics Education Program (CGEP), and a bilingual licensed, board-certified cancer risk genetic counselor with the Division of Clinical Cancer Genetics at City of Hope. Dr. Blazer has worked the development, administration and assessment of the NCI-funded initiatives of the CGEP (a multifaceted cancer genetics education and training program for physicians, allied health care professionals and post-doctoral researchers) since joining the division in 1998. The outcomes and theoretical framework her education research serve as the cornerstone of the Intensive Course and Clinical Cancer Genomics Community of Practice (CCGCoP), which brings cancer genetics practitioners from diverse practice settings together for professional learning and enduring patient-centered support across the U.S. and internationally.
Co-PIs Dr. Blazer and Dr. Jeffrey Weitzel were recipients of the 2019 American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education, in recognition of the scope and reach of their education initiatives. Dr. Blazer is a member of the American Society of Human Genetics, the National Society of Genetic Counselors, the American Association of Cancer Education, and the National Human Genome Research Institute Inter-Society Coordinating Committee for Practitioner Education in Genomics.
Michael Caligiuri, MD
President, City of Hope National Medical Center; Deana and Steve Campbell Physician-in-Chief
Michael Caligiuri, MD, is president of City of Hope National Medical Center, the Deana and Steve Campbell Physician-in-Chief Distinguished Chair of City of Hope. A renowned physician, scientist, builder, innovator, leader and visionary, Dr. Caligiuri is dedicated to developing the next generation of leading-edge cancer therapies, rapidly delivering them to patients and ultimately curing the disease. Prior to joining City of Hope, he was a physician, scientist and program leader in the cancer program at The Ohio State University. He served as CEO of The James Cancer Hospital and Solove Research Institute and he directed The Ohio State University Comprehensive Cancer Center for 14 years, recruiting over 300 cancer physicians and scientists. He has been recognized with myriad honors and awards throughout his career, including the Director’s Service Award and the MERIT Award and an Outstanding Investigator Award from the NCI, the John Wayne Clinical Research Award from the Society of Surgical Oncologists, and the Emil J Freireich Award in Clinical Cancer Research from The University of Texas MD Anderson Cancer Center. He is an elected fellow of the American Association for the Advancement of Science, the American College of Physicians, and the Alpha Omega Honor Medical Society, as well as an elected member of the Association of American Physicians and the American Society for Clinical Investigation. Dr. Caligiuri was elected to the National Academy of Medicine’s Class of 2018 for his outstanding professional achievements and commitment to service, including his breakthrough discoveries in natural killer cell (NK) leukemia and cutaneous T cell lymphoma. He is also the immediate past president of the American Association for Cancer Research, and he was also recently named a fellow of the AACR.
Yanin Chavarri Guerra, MD, MSc
Principal Investigator in Hemato-Oncology Department, Salvador Zubiran National Institute of Medical Sciences and Nutrition, Mexico City, Mexico
Yanin Chavarri-Guerra, MD, MSc, is a member of the faculty at the National Institute of Medical Sciences and Nutrition (INCMNSZ) in Mexico City,, where she is dedicated to the treatment of breast cancer patients. Following her clinical oncology fellowship at INCMNSZ she completed a fellowships in Breast Cancer Research at Massachusetts General Hospital, and a postdoctoral fellowship in Cancer Genetics at City of Hope in 2017. Dr. Chavarri is a Co-Investigator in the international study “Molecular Genetics Studies of Cancer Patients and Their Relatives¨ from City of Hope, and the Principal Investigator in several investigator-initiated basic and epidemiological studies. Her research focuses on disparities in access to cancer care in low and middle-income countries, particularly focused on breast cancer in Mexico. Currently, Dr. Chavarri-Guerra leads two investigator-initiated studies at INCMNSZ, including a patient navigation study to improve access to supportive care for patients with advanced cancer in Mexico City. She received the National Award for Research in Oncology from the Mexican Society of Oncology (2008), the International Development Award (2010) and the International Innovation Grant (2015) from the American Society of Clinical Oncology (ASCO) and the Conquer Cancer Foundation (CCF). She is currently a member of the National System of Investigators of the National Council of Science and Technology in Mexico (CONACYT) and of the System of Investigators of the National Institutes of Health of Mexico.
Fergus J. Couch, PhD
Fergus J. Couch, Ph.D. is a Professor and Chair of the Division of Experimental Pathology and Laboratory Medicine within the Department of Laboratory Medicine and Pathology at the Mayo Clinic. He holds joint appointments in the Departments of Health Sciences Research and Biochemistry and Molecular Biology. Dr. Couch works on the genetics of breast cancer, with over 300 publications relating to the discovery and clinical characterization of inherited genetic variants in cancer susceptibility genes. Dr. Couch is the principal investigator of the Mayo Clinic Breast Cancer Registry and is a founder and a member of the coordinating committee of CIMBA (the consortium of investigators of modifiers of BRCA1/2) that is focused on identifying genetic modifiers of breast cancer risk in the BRCA1 carrier population. Similarly, he is the principal investigator of the Triple Negative Breast Cancer Consortium (TNBCC), aimed at understanding the genetic etiology of triple negative breast cancer, and is a long-term contributor to the international Breast Cancer Association Consortium (BCAC). Dr. Couch is a co-founder of the Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) consortium that is focused on establishing the clinical relevance of variants of uncertain significance (VUS) in BRCA1 and BRCA2. Within ENIGMA, he is coordinating the “Other Predisposition Gene Working Group” in an effort to characterize the risk and penetrance of deleterious mutations and VUS in non-BRCA1/2 predisposition genes. He has also collaborated with investigators from Memorial Sloan Kettering Cancer Center and the University of Pennsylvania to develop the Prospective Registry Of Multi-Plex Testing (PROMPT) for patients with mutations in predisposition genes. Finally, Dr. Couch is a founding member and participant in COMPLEXO, a consortium of investigators aiming to identify additional breast cancer predisposition genes.
David Duggan, Ph.D.
Technical Advisor to the Chief Operating Officer of the Translational Genomics Institute (TGen)
David Duggan, PhD, Technical Advisor to the Chief Operating Officer of the Translational Genomics Institute (TGen), is a leading translational genomics researcher and technical analyst with 28 years of scientific expertise and more than a decade of experience advising equity management firms on many of the leading genomics and personalized medicine companies. His discovery-based research and translational genomics interests are focused on the discovery and validation of novel genetic- and or genomic-based biomarkers for complex diseases, including cancer and translating clinically validated and useful findings to improve individual and population risk prediction, early detection, diagnostics, prognostics, and or therapeutic decision-making. With the use of state-of-the-art study designs and advanced genomic technologies, Dr. Duggan’s TGen laboratory has generated data on >300,000 study participants. His lab was among the first groups to propose GWAS studies and published one of the first polygenic risk score papers (Zheng et al., NEJM 2008). He has been an investigator on 26 NIH funded grants and a key member of numerous consortiums including NCI’s Colon Cancer Family Registry Consortium (CCFR), NCI’s Breast Cancer Family Registry (BCFR), NHGRI’s Population Architecture of Genomics and Epidemiology (PAGE), NCI’s Women’s Environmental, Cancer, and Radiation Epidemiology (WECARE), NCI’s Genetic Epidemiology of Colorectal Cancer Consortium (GECCO), and NCI’s International Consortium on Prostate Cancer Genetics (ICPCG). Dr. Duggan received his Ph.D. in human genetics from the University of Pittsburgh and obtained his post-doctoral training at the National Human Genome Research Institute, National Institutes of Health.
Judy Garber, MD, MPH
Director, Center for Cancer Genetics and Prevention
Dana Farber Cancer Institute
Dr. Garber is the Director of the Cancer Genetics and Prevention Disease Center at Dana-Farber Cancer Institute and a Professor of Medicine at Harvard Medical School. Dr. Garber conducts research in clinical cancer genetics, with a special focus in the genetics of breast cancer. She has played a major role in the development of national guidelines in cancer genetics. She is also a leader in research into the characteristics and treatment of triple negative or basal-like breast cancer, the most common form in women with BRCA1 mutations. Her translational research focuses on the evaluation of novel agents targeting DNA repair defects in breast cancer, including PARP inhibitors for treatment and prevention of breast cancer and other BRCA-associated cancers.
In 2011-2012, Dr. Garber was the President of American Association for Cancer Research (AACR), the largest organization of cancer researchers in the world. She is a member of the National Cancer Advisory Board and was recently elected to the Institute of Medicine.
Veda Giri, MD
Associate Professor in Medical Oncology and Cancer Biology at Sidney Kimmel Cancer Center
Thomas Jefferson University
Veda N. Giri, MD is an Associate Professor in Medical Oncology and Cancer Biology at Sidney Kimmel Cancer Center at Thomas Jefferson University. She is a medical oncologist with a clinical and research interest in inherited cancer risk assessment. Dr. Giri has recently assumed the position of Director of Cancer Risk Assessment and Clinical Cancer Genetics at Thomas Jefferson University, where her role will be to lead an integrated and comprehensive effort in inherited cancer risk assessment and conduct studies focused on genetic evaluation of cancer risk. Her clinical efforts will be focused on genetic evaluation of inherited risk for GU cancers, specifically prostate, kidney, and upper tract urothelial cancers. Research studies will encompass genetic characterization of cancer risk using sequencing technologies, molecular signatures, and novel biomarkers to ultimately reduce cancer-related morbidity and mortality. Her research also has a strong focus in cancer disparities.
Dr. Giri received her medical degree from Jefferson Medical College, and proceeded to complete her residency in Internal Medicine and fellowship in Hematology-Oncology at the University of Michigan. She then completed advanced training in molecular cancer genetics at Fox Chase Cancer Center (FCCC). From 2006-2014, she directed prostate cancer risk assessment at FCCC, developing studies focused on evaluating the role of genetic markers in prostate cancer risk assessment. Dr. Giri has served on national committees including the National Comprehensive Cancer Network Prostate Cancer Early Detection Panel and NIH PDQ® Cancer Genetics Editorial Board, contributing expertise in cancer risk assessment and prostate cancer genetics.
Stacy W. Gray, MD
Associate Clinical Professor, Department of Medical Oncology
City of Hope
Dr. Gray received her MD from the University of Chicago Pritzker School of Medicine. She completed her residency in Internal Medicine and her fellowship in Hematology/Oncology at The University of Chicago Hospitals. While in fellowship, Dr. Gray obtained a Masters degree in Public Policy from the University of Chicago Harris School. After fellowship, Dr. Gray completed a post-doctoral research fellowship in cancer communication at the University of Pennsylvania. In 2008, she joined the faculty of the Dana-Farber Cancer Institute, the Brigham and Women's Hospital and Harvard Medical School where she worked as a medical oncologist and cancer outcomes researcher in the division of Population Sciences and the Lowe Center for Thoracic Oncology. In the fall of 2016, Dr. Gray moved to The City of Hope Medical Center as an Associate Professor in the Department Medical Oncology, Population Sciences, Division of Clinical Cancer Genetics. Dr. Gray currently serves as the Deputy Director of the Center for Precision Medicine and the Division Chief for Clinical Cancer Genomics at the City of Hope.
Dr. Gray’s research focuses on understanding the medical and psychosocial outcomes related to the use of genomic technologies in cancer care. One of Dr. Gray’s goals is to understand the relationships between information dissemination, on an individual and population level, and the adoption of personalized cancer technologies. Dr. Gray also studies the clinical implementation of cancer whole-exome sequencing (WES), the "actionability" of sequence data in different populations, the integration of genomic data into the electronic health record and the social and behavioral science methods that can be used to answer emerging questions in cancer dissemination and implementation research. Dr. Gray’s overall goal is to gain a better understanding of how a variety of factors may be working to drive the use of new genomic technologies and design targeted interventions to improve the delivery of personalized cancer care.
Stephen B Gruber, M.P.H., MD, PhD,
Director of the Center of Precision Medicine at City of Hope Medical Center
Stephen Gruber, MD, PhD, MPH is Director of the Center of Precision Medicine at City of Hope Medical Center. Dr. Gruber is a board-certified medical oncologist, cancer geneticist and epidemiologist whose research focuses on genetic and environmental contributions to cancer. His particular research interests include the genetic epidemiology of cancer, with emphasis on colorectal cancer; the molecular pathogenesis of cancer, integrated with genetic epidemiology; methods in genetic and molecular epidemiology; and clinical cancer genetics and translational research in cancer prevention. He has received a number of honors and awards and is the author of more than 158 peer-reviewed publications related to his work in the field of cancer genetics, particularly as it relates to colorectal cancer. In addition to serving on editorial boards for several professional journals, Dr. Gruber is active in national organizations. Since 2005, he has been Chair of the Colorectal Family Registries Advisory Panel for the National Cancer Institute and for the past three years chaired the Cancer Genetics Education Committee of the American Society of Clinical Oncology. Dr. Gruber obtained his Master of Public Health Degree from Yale University in 1986. After completing his Doctorate Degree in Epidemiology at Yale in 1988, he obtained his al Medical Degree from the University of Pennsylvania Medical School in 1992, where he also completed his internship and residency. He completed fellowships in medical oncology at Johns Hopkins Hospital and in clinical medical genetics at the University of Michigan.
Kent Hoskins, MD
Associate Professor of Medicine at the University of Illinois at Chicago
Kent Hoskins, MD is an Associate Professor of Medicine at the University of Illinois at Chicago where he is director of Cancer Genetics and co-Leader of the Breast Cancer Research Group in the University of Illinois Cancer Center. He is a Medical Oncologist who specializes in the treatment of breast cancer and genetic evaluation of individuals with hereditary breast cancer risk. Early in his career he was part of a team at the University of Michigan and then at the University of Pennsylvania that was involved in efforts to clone the BRCA1 gene. . His work involves efforts to identify the biological underpinnings of the poor outcomes observed in African-American women with breast cancer. Currently his research focuses on developing a population health strategy for identifying individuals with hereditary cancer risk in the primary care setting, with an emphasis on health disparities.
Beth Y. Karlan, MD
Professor, Department of Obstetrics and Gynecology
Beth Y. Karlan, MD is nationally renowned leader in the diagnosis and treatment of women's reproductive cancers. She is referred complex and difficult cases from around the country. She is Director of Gynecologic Oncology at Cedars-Sinai Medical Center, and one of the four gynecologic oncologists heading the international referral and treatment program for Ovarian Cancer at the Cedars-Sinai Comprehensive Cancer Center. Dr. Karlan’s research focuses on ovarian cancer specific biomarkers for early detection, prognostication and targeted/individualized therapy, and inherited cancer susceptibility. She is a recipient of numerous awards and honors for excellence in the fields of cancer treatment and research. and has published over 80 articles, books and abstracts. She also serves as the Director of the Gilda Radner Ovarian Detection Program at Cedars-Sinai Medical Center. A noted speaker, Dr. Karlan has spoken as guest lecturer at medical centers and conventions throughout the world. She serves as an editorial consultant and reviewer for numerous cancer and obstetrics and gynecology journals, including the Journal of Women's Health and Gynecologic Oncology.
Seema A Khan, MD
Bluhm Family Professor of Cancer Research & Co-Leader, Cancer Prevention Program
Seema Khan, MD is co-Leader of the Cancer Prevention Program and a surgical oncologist. She has specific interest in biomarkers of breast cancer risk that can be identified in minimal samples of breast epithelium. Her research projects include investigation of RNA and microRNA biomarkers in benign biopsy material, that will serve to better stratify breast cancer risk, and as targets for specific prevention interventions. She has conducted early phase prevention trials, which currently focus on the evaluation of topical transdermal drug delivery to the breast. Her laboratory interests include the investigation of progesterone signaling in the breast, in the context of early events that relate to cancer prevention. She is the chair of a Phase III ECOG trial of local therapy for the intact primary tumor in women with Stage IV breast cancer (E2108), and of a Phase II trial testing the use of MRI and DCIS Score in women with DCIS.
Elisabeth King, MSN, RN, FNP-C, AGN-BC
Elisabeth King, RN, FNP, AOCNP, AGN is a nurse practitioner and the senior manager of Genomic Cancer Risk Counseling in the Division of Clinical Cancer Genomics at City of Hope. Ms. King joined City of Hope in 2018 from Texas Oncology, where she helped lead and support the Advanced Practice Provider and Genetics programs throughout the state. She is a family nurse practitioner and also holds advanced nursing certifications in oncology and genetics. She received her bachelor’s degree in biology with a focus on genetics and biotechnology from University of Texas at Austin. She earned her master’s degree in nursing at Frontier Nursing University. King is an alumnus and clinical faculty member of the City of Hope Intensive Course in Cancer Risk Assessment.
Bita Nehoray, MS, CGC
Senior Genetic Counselor
City of Hope
Bita Nehoray, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree in Human Genetics and Genetic Counseling from Stanford University. Ms. Nehoray joined the City of Hope Division of Clinical Cancer Genomics in 2012, where she provides cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer, with a focus in Li-Fraumeni syndrome. She is fluent in Spanish and Farsi and is committed to advancing the provision of cancer genetics services to medically underserved and culturally diverse populations. Other clinical responsibilities include providing pro-bono cancer genetic counseling services to underserved Latino families through an outreach program established by the Division of Clinical Cancer Genomics and supported through government and foundations grants and compassionate funding. Current research projects include understanding cancer risk, penetrance, prevalence, and clinical outcomes for individuals with TP53 mutations as part of the LiFT Up study, evaluating the spectrum of germline variants in Israeli breast cancer patients, and assessing Community-based provider experiences with polygenic risk scores in genetic cancer risk assessment. She serves on the Genetic Counseling Advisory Committee for the Li-Fraumeni Syndrome Association. She is an active member of the National Society of Genetic Counselors, Southern California Genetic Counselors, and the American Society of Human Genetics.
Olufunmilayo I. Olopade, MD, FACP
Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics
Olufunmilayo Falusi Olopade, MD, FACP, OON is the Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics and founding director of the Center for Clinical Cancer Genetics at the University of Chicago Medicine. She is an expert in cancer risk assessment and individualized treatment for the most aggressive forms of breast cancer, having developed novel management strategies based on an understanding of the altered genes in individual patients. She stresses comprehensive risk reducing strategies and prevention in high-risk populations, as well as earlier detection through advanced imaging technologies. Dr. Olopade has received numerous honors and awards, including honorary degrees from North Central, Dominican, Bowdoin and Princeton universities. She is also a recipient of the Doris Duke Distinguished Clinical Scientist and Exceptional Mentor Award, an American Cancer Society Clinical Research Professorship, a MacArthur Foundation "Genius" Fellowship and Officer of the Order of the Niger Award. Dr. Olopade is an elected member of the American Academy of Arts and Sciences and the American Philosophical Society. She currently serves on the board of directors for the American Board of Internal Medicine, the National Cancer Advisory Board, Susan G. Komen for the Cure, Cancer IQ and the Lyric Opera of Chicago.
Colin Pritchard, MD, PhD
University of Washington
Dr. Pritchard is an Assistant Professor of Laboratory Medicine, as well as the associate director of the genetics and solid tumors laboratory at the University of Washington Medical Center that services the Seattle Cancer Care Alliance (SCCA) that includes Seattle Children’s hospital. Dr. Pritchard undertook his undergraduate and graduate training at the University of Washington in Seattle in the United States. He completed his medical training at the University of Washington School of Medicine. The Pritchard laboratory focuses on oncology molecular diagnostics, particularly the source and utility of cell-free nucleic acid biomarkers in blood, and the development of innovative molecular diagnostics for the identification of mutations that can guide therapeutic decision-making. His clinical work focuses on applications of next-generation sequencing gene panels for cancer risk assessment and precision treatment. He has led the development and implementation of the ColoSeq™ Lynch and Polyposis Syndrome Panel and UW-OncoPlex™ Cancer Gene Panel in current clinical use for cancer patients and their families.
Mark E. Robson, MD
Mark Robson, MD is Chief of the Breast Medicine Service in the Department of Medicine at Memorial Hospital in New York, an attending physician on Breast Medicine and Clinical Genetics Services, and a member of the Memorial Sloan Kettering Cancer Center. His clinical research has concentrated on the optimal application of germline information to the management of cancer patients, particularly those with breast cancer. He has been a lead investigator for a number of trials of PARP inhibitors in patients with BRCA associated breast cancer. He is currently developing new models for the acquisition of germline information, including "mainstreaming" through test ordering by primary oncology providers and broad genomic screening in the context of somatic mutation profiling. He is also investigating the use of polygenic risk scores in facilitating decision-making among women with or without an inherited predisposition. Dr. Robson serves on the editorial board of the Journal of Clinical Oncology and is an associate editor for the Journal of the National Cancer Institute and Genetics in Medicine. He is also the past chair of the Ethics Committee of the American Society of Clinical Oncology and has served several terms on the ASCO Cancer Prevention Committee and its Cancer Genetics subcommittee. Dr. Robson graduated from the University of Virginia School of Medicine in Charlottesville, Virginia, and did his internal medicine residency and hematology-oncology fellowship training at Walter Reed Army Medical Center in Washington DC.
Iris Romero, MD, MS
Associate Professor and research scientist in the Department of Obstetrics & Gynecology
Iris Romero, MD, MS is an Associate Professor and research scientist in the Department of Obstetrics & Gynecology and the Dean for Diversity and Inclusion for the Biological Sciences Division of the University of Chicago. Since joining the faculty in 2007, Dr. Romero has successfully merged a career in cancer biology with clinical application to provide cutting edge, quality healthcare for women. Her clinical practice is focused on hereditary breast and ovarian cancer, and includes care for women with genetic predisposition for cancer and general obstetrics and gynecology. She also has a translational research lab aimed at identifying agents, like metformin, that can be repurposed to target the ovarian cancer tumor microenvironment. She has received NIH funding through the national Reproductive Scientist Development Program. Her research has been published in top scientific journals including Nature, Obstetrics & Gynecology, American Journal of Obstetrics and Gynecology, and Gynecologic Oncology. Dr. Romero attended University of New Mexico for medical school and completed OB/Gyn residency at University of Utah and she completed training in hereditary cancer genetics through the City of Hope.
Thomas Slavin, MD, FACMG, DABMD
Senior Vice President of Medical Affairs for Oncology
Dr. Slavin is Senior Vice President of Medical Affairs for Oncology at Myriad Genetics. He is a physician-scientist, triple-board-certified in clinical genetics, molecular diagnostics and pediatrics. Most recently, he served as assistant professor in the departments of Medical Oncology & Therapeutics Research and Population Sciences at City of Hope National Medical Center. Dr. Slavin graduated medical school with Alpha-Omega-Alpha-honors from the University of South Florida. He completed his residency programs at Case Western Reserve in Cleveland, Ohio; this training included a postdoctoral research year in genetic epidemiology. He has also completed graduate course work towards a Masters degree in clinical research through the University of Southern California. He is an active member of the American Association of Cancer Research, the American Society of Clinical Oncology (ASCO), the American Society of Human Genetics, the Collaborative Group of the Americas on Inherited Colorectal Cancer, and is a fellow of the American College of Medical Genetics and Genomics. He has served on National Comprehensive Cancer Network (NCCN)committees for both the genetics of and screening for colorectal cancer. He has served on three ClinGen expert working group committees for variant classification of breast, gastrointestinal and ovarian cancer predisposition genes. Focused on expanding genetics education for cancer care providers, Dr. Slavin has helped shape both ASCO University as well as City of Hope’s hereditary genomics training program. He is a well-published researcher in the field of medical genetics, including over 60 journal articles, multiple book chapters, and numerous presentations at national and international medical meetings. He has been involved in many national cancer research grants, and was a 2018 National Institutes of Health (NIH) K08-career development grant awardee.
Jeffrey Weitzel, MD
Professor of Oncology and Population Sciences
Jeffrey N. Weitzel, MD, is board Certified in Medical Oncology and Clinical Genetics, and founded the Clinical Cancer Genomics Community Research Network. He co-founded the Clinical Cancer Genomics Community of Practice with Dr. Blazer. A Breast Cancer Research Foundation Scholar and an honorary Professor of Oncology for the Latin American School of Oncology, he is also the ASCO Conquer Cancer Research Professor in Breast Cancer Disparities. At the vanguard of precision prevention, Dr. Weitzel’s multidisciplinary clinical, research, and training experience emphasize translational research in cancer disparities, genomic cancer risk assessment, chemoprevention, targeted therapy, clinical and psychosocial outcomes, genetic epidemiology and health services research, with a focus on underserved populations. Dr. Weitzel received the American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education.
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ATM Gene and Breast Cancer
"Risk Reduction Gastrectomy and Consequences" presented on November 6th, 2015 by Yanghee Woo, MD
during City of Hope's Division of Clinical Cancer Genetics Community of Practice Weekly Topics in Cancer Genetics Research (TICGR).
Yangehee Woo, MD, FACS
Associate Professor of Clinical Surgery
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Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS)
"Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS)" presented on 11/3/17 by Grace-Ann Fasaye, ScM, CGC during City of Hope's Division of Clinical Cancer Genomics Community of Practice Weekly Topics in Cancer Genetics Research (TICGR).
Grace-Ann Fasaye, GC
Grace-Ann Fasaye is a genetic counselor for the Genetics Branch at the National Cancer Institute (NCI). Prior to joining the NCI, Grace-Ann was a program manager or research coordinator for genetic counseling projects at various community and academic hospitals in the Washington, DC metropolitan area. In her current role at the NCI, she provides genetic counseling to patients with a personal and/or family history of rare tumors including GIST, diffuse gastric cancer, and mesothelioma. She also serves as a rotation supervisor to genetic counseling graduate students and provides genomics training to experienced health care professionals. Grace-Ann received her master's degree from the joint Johns Hopkins School of Public Health and National Human Genome Research Institute’s Genetic Counseling Training Program in 2000 and is an alumna of the 2010 City of Hope Intensive Course in Cancer Risk Assessment.
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Multi-Tasking Nurse Practitioners Take On GCRA
"Multi-Tasking Nurse Practitioners Take on GCRA" by Daisy Boehm APNP, AOCNP and Krystal Schepp APNP
Daisy Boehm, APNP
Daisy is Board Certified as a Family Nurse Practitioner. She earned her Master’s Degree from the University of Wisconsin-Oshkosh and her Bachelor’s Degree from University of Wisconsin- Madison. Before obtaining her advanced degree, Daisy worked as a registered nurse on the pediatric/gynecology unit at St. Elizabeth Hospital. She holds an advanced certification as an Advanced Oncology Certified Nurse Practitioner. She is a member of the American Academy of Nurse Practitioners, Wisconsin Nurse’s Association and Oncology Nursing Society. Daisy enjoys knitting, reading, watching movies, running, practicing yoga and also teaches yoga. Daisy and her husband, Chris, enjoy traveling, attending sports events and spending time with family and friends.
Krystal Schepp, APNP
Krystal Schepp is Board Certified as an Adult & Gerontology Nurse Practitioner. She earned her Master’s Degree from Marian University in Appleton, Wisconsin and her Bachelor’s Degree from University of Wisconsin-Oshkosh. She has been a Nurse Practitioner with Fox Valley Hematology & Oncology for over two years, serving both medical and radiation oncology patients. Before obtaining her advanced degree, Krystal worked as a registered nurse in an intensive care unit. She is a member of the American Academy of Nurse Practitioners as well as the Oncology Nursing Society.
Krystal and her husband, Michael, enjoy cooking, spending time at the lake with family, attending Brewers and Packer games. Krystal also enjoys playing volleyball and biking.
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The evolving phenotype of Li-Fraumeni Syndrome
The evolving phenotype of Li-Fraumeni Syndrome
Huma Q. Rana, MD
Clinical Director, Cancer Genetics and Prevention
Dr. Huma Rana is a physician at Dana Farber Cancer Institute, board certified in Internal Medicine and Clinical Genetics. She received her medical degree from the Robert Wood Johnson Medical School, completed her Internal Medicine and Genetics training at Mount Sinai School of Medicine in New York, and joined Dana-Farber in 2012.
At Dana-Farber, she is the Clinical Director of the Center for Cancer Genetics and Prevention. She provides longitudinal medical management of patients with hereditary cancer predispositions, and also leads multiple research projects studying various hereditary cancer syndromes. She is currently leading a research study on genotype-phenotype correlations in Li-Fraumeni syndrome.
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Implementation of a Telegenetics program in a High Risk Breast Clinic
Presenters: Kate Hunley, APRN, WHNP & Michelle Wehrly, NP
Presentation Title: ""Implementation of a Telegenetics program in a High Risk Breast Clinic"
Kate Hunley, APRN, WHNP
Kate Hunley, APRN, WHNP is the Nurse Practitioner for the Henry Lynch Cancer Center CHI Health Breast Health Center at Lakeside Hospital in Omaha, Nebraska. She graduated from Creighton University in Omaha, Nebraska with her Bachelor of Science in Nursing in 2003. She worked at the bedside in OB and NICU while pursuing her Master’s. She received her Master’s of Nursing Degree in Women’s Health from the University of Nebraska Medical Center in 2012. Kate is a Board Certified Women’s Health Nurse Practitioner through the NCC. She is a participating member of the ONS.
Kate worked as a Nurse Practitioner with patients in community health prior to coming to this position at Lakeside. In her first 6 months at the Breast Center, she has completed over 90 hours of Continuing Education in Oncology and Genetics classes through ONS, CHI Health, and NCCN. She attended the Hereditary Breast and Ovarian Cancer Conference in Montreal, Canada in May 2016. She actively seeks educational opportunities to enhance her knowledge of Cancer Genetics.
She continues to participate in the planning and initiation of the High Risk Clinic within the Breast Health Center. She facilitates and participates in weekly Breast Cancer Conferences which allows her further opportunity to identify at risk patients.
Michelle Wehrly APRN-NP
Michelle Wehrly is a Nurse Practitioner in general surgery in the Omaha, NE area. She works with two general surgeons and a portion of her duties includes caring for breast and colon cancer patients. She previously worked at a Breast Health and Lung Health Center and followed patients with malignant and benign conditions. She attended the University of Nebraska Medical Center for graduate school and while there did research focusing on gynecological history of breast cancer survivors with bone loss. She has an interest in oncology that began in nursing school and her first nursing job was on an oncology floor. She is a member of Nebraska Nurse Practitioner.
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Establishing a High Risk Breast Clinic in a Community-Based Health System
"Establishing a High Risk Breast Clinic in a Community-Based Health System" presented on 10/13/17 by Anne Stoltenberg, MSN, RN during City of Hope's Division of Clinical Cancer Genomics Community of Practice Weekly Topics in Cancer Genetics Research (TICGR)
Anne Stoltenberg, MSN, RN, ACNP-BC
Anne Stoltenberg is the nurse practitioner for the High Risk Breast Clinic on the All Saints and Franklin campuses of Wheaton Franciscan Healthcare located in Southeastern Wisconsin. She is board certified as a nurse practitioner in acute care by the American Nurses Credentialing Center and serves as adjunct faculty for the College of Nursing at the University of Wisconsin-Milwaukee.
Anne’s primary focus is on the clinical care of women who are at increased risk of developing breast cancer. Areas of emphasis include familial/genetic risk assessment, clinical exam and development of an evidence-based plan of care for surveillance. Additional emphasis is placed on educating women on risk factors for developing breast cancer and how to modify those risk factors through lifestyle changes and/or chemoprophylaxis. She is a member of the International Society of Nurses in Genetics and Sigma Theta Tau Nursing Honor Society.
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Direct to Consumer Testing and Cancer Genetics
"Direct to Consumer Testing and Cancer Genetics" presented on September 15th 2017 by Allison M. Jay, M.D. during City of Hope's Division of Clinical Cancer Genomics Community of Practice Weekly Topics in Cancer Genetics Research (TICGR).
Allison M. Jay
Dr. Jay completed a medical genetics residency at Wayne State and was fortunate to train with Dr.Michael Simon and Nancie Petrucelli who run the genetics program at Karmanos Hospital. During her residence she collaborated with Dr.Simon on research initiatives in the Women’s Health Initiative, and this collaboration is ongoing.
After her residency, she completed a fellowship in biochemical genetics at the Mayo Clinic where she had the opportunity to see clinical cancer genetics patients with the counselors there. After completing her fellowship at the Mayo Clinic, in October of 2014, Dr.Jay joined St.John Hospital and began working at the VanElslander Cancer Center as the Director of the Cancer Genetics program.
Since starting, the program has grown from 10 patients a month to 60 patients. In addition to her work at St.John she is a voluntary faculty member at Wayne State and is involved in teaching the year one medical genetics course, and also supervises genetic counseling students from the Wayne State Genetic Counseling Training Program. Dr.Jay hopes through this course to gain further information and other collaborators who can help her make the best informed care decisions for her patients, and also share the knowledge with students and residents who train with her.
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Building a Community High Risk Breast Cancer Screening Program
"Building a Community High Risk Breast Cancer Screening Program" presented by Karen Herold, DNP during City of Hope's Division of Clinical Cancer Genomics Community of Practice Weekly Topics in Cancer Genetics Research (TICGR).
Karen Herold, DNP, WHCNP-BC, FNP-BC
High Risk Breast Care Nurse Practitioner
Karen Herold is the high risk breast cancer nurse practitioner at Hoag Memorial Hospital in Newport Beach, CA. Karen has worked in hospital, research, private practice and academic settings. She obtained her B.S. in Chemistry, and her Women’s Health Nurse Practitioner degree from Harbor-UCLA and her Family Nurse practitioner and Doctorate degree from Case Western Reserve in Ohio.
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Hereditary Cancer Prevention & Mgmt. Center
"Hereditary Cancer Prevention & Management Center – Development of a High Risk Clinic in a Community Setting" presented on August 11th 2017 by Michael P. Mullane,M.D. and Brenda Ramczyk, RN during City of Hope's Division of Clinical Cancer Genomics Community of Practice Weekly Topics in Cancer Genetics Research (TICGR).
Brenda Ramczyk, RN, OCN, BSN
Brenda Ramczyk, RN, OCN, is the Nurse Navigator for the Hereditary Cancer Prevention and Management Center at Aurora Health Care in Wisconsin. She has partnered with Aurora Genetic Counselors and Medical Oncologist Michael P. Mullane, MD to develop this clinic.
Brenda has been interested in the relationship of cancer genetic testing and patient care reaching back to early 2000 when she was part of the Jane Cremer Women's Cancer educational program hosting Dr. Jeffrey Weitzel to speak about genetics in breast cancer in Racine, Wisconsin. Since then, she has also worked with Myriad Genetics in 2007 and 2008 to bring a series of five speakers to Oncology Alliance in Milwaukee, Wisconsin to educate Physicians, Advanced Practice Providers and Nurses about genetic risk assessment and appropriateness of genetic testing. Brenda has continued to seek knowledge regarding inherited cancer syndromes and cancer genetics by completing the Oncology Nursing Society Cancer Genetics course. She has also attended the past three genetics conferences sponsored by The University of Chicago Medicine and City of Hope when they have been located in Chicago.