8th Annual Clinical Cancer Genomics Conference Recordings

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8th Annual Clinical Cancer Genomics Conference - From Exceptionalism to Exceptional Care: Mainstreaming Genomic Medicine In Clinical Practice

Rapid advances in next generation sequencing (NGS) technologies and market forces are driving a surge in demand for Genomic Cancer Risk Assessment (GCRA) services across the nation. Clinicians must be adequately prepared with the knowledge and skills needed to address the complexities associated with multigene panel testing, polygenic risk scores (PRS), and approaches that combine tumor and germline genomic profiles. This two-day conference brings a roster of nationally recognized speakers together with community-based clinicians from across the U.S. and personalized cancer risk assessment, treatment and preventive care.

Learning Objectives:

  • At the conclusion of this activity attendees will be able to:
  • Identify the benefits and limitations of applying NGS information into cancer genetic/genomic risk assessment
  • Examine the challenges related to broad genomic analyses, such as panels or exomes, that yield incidental findings
  • Discuss the clinical utility of polygenic risk scores in cancer risk assessment
  • Apply evidence-based cancer screening and prevention recommendations to clinical cases with pathogenic variants in moderate risk genes
  • Discern the significance of germline findings in somatic tumor testing
  • Recognize the importance of clinical-research collaborations to characterize lesser-known cancer risk genes

Antonis Antonious, PhD

Professor of Cancer Risk Prediction Academic Course Director MPhil Epidemiology

Antonis Antoniou, PhD is the Professor of Cancer Risk Prediction in the Department of Public Health and Primary Care, and Academic Course Director for the MPhil in Epidemiology at the University of Cambridge. He studied at the London School of Economics and Political Science and the University of Cambridge before gaining his PhD in Genetic Epidemiology at Cambridge in 2001Professor Antoniou’s primary research focus is the development and application of statistical modelling techniques for addressing clinical questions, and the development of risk prediction tools that are used in clinical practice.  His research focuses on two broad areas: (1) The development and evaluation of risk prediction models for familial breast, ovarian, prostate and other common cancers; and (2) The characterization of cancer risks for genetically susceptible individuals, such as those carrying mutations in the BRCA1, BRCA2, PALB2, RAD51Cand RAD51D genes. Dr. Antoniou is a leader in the development and evolution of Boadicea, a comprehensive model designed to enable personalized breast cancer risk stratification and informed decision-making on prevention therapies and screening in the general population and in women with family history.

Leslie G. Biesecker, MD

Chief & Senior Investigator

Leslie Biesecker, MD, Is a clinical and molecular geneticist and Chief of the Medical Genomics and Metabolic Genetics Branch at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health. He received his medical training at the University of Illinois, training in pediatrics at the University of Wisconsin, and in clinical and molecular genetics at the University of Michigan. Dr. Biesecker’s research focuses on rare disorders of development and growth, and to new approaches to clinical genomics. His laboratory has elucidated the etiology and natural history of numerous diseases, including Proteus syndrome, PIK3CA-related overgrowth syndrome, TARP syndrome, oculofaciocardiodental syndrome, Lenz microphthalmia syndrome, McKusick-Kaufman syndrome, Bardet-Biedl syndrome, Pallister-Hall syndrome and Amish microcephaly, and has contributed to the discovery of many others. Dr. Biesecker is Principle Investigator of the ClinSeq® program, which to date has consented more than 1,000 subjects to participate in whole-genome sequencing, the mission of which is to develop new approaches to analyze and store genomic data, and to identify the best ways to share genetic information with participants and families.

Kathleen R. Blazer, EdD, MS, CGC

Assistant Professor, Director Cancer Genomics Education Program

Kathleen R. Blazer is a Clinical Assistant Professor in the Department of Population Sciences, Director of the Cancer Genomics Education Program (CGEP), and a bilingual licensed, board-certified cancer risk genetic counselor with the Division of Clinical Cancer Genetics at City of Hope. Dr. Blazer has worked with Co-Principle Investigator Dr. Jeffery Weitzel in the development, administration and assessment of the National Cancer Institute-funded initiatives of the CGEP (a multifaceted cancer genetics education and training program for physicians, allied health care professionals and post-doctoral researchers) since joining the division in 1998. She has first-authored a number of peer-reviewed publications reporting the development and outcomes of the professional education and training research activities conducted by the CGEP. Her doctorate in education research worked within the setting of the CGEP to examine the effectiveness of distance-mediated approaches to cancer genetics training. The outcomes and theoretical framework of her dissertation research serve as the cornerstone of the Intensive Course and Clinical Cancer Genomics Community of Practice (CCGCoP), which brings cancer genetics practitioners from diverse practice settings together for professional learning, enduring patient-centered support and community-based research collaborations across the U.S. and internationally. Drs. Blazer and Weitzel were co-recipients of the 2019 American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education in recognition of the scope and reach of their education initiatives. Dr. Blazer is a member of the American Society of Human Genetics, the National Society of Genetic Counselors, the American Association of Cancer Education, and the National Human Genome Research Institute Inter-Society Coordinating Committee for Practitioner Education in Genomics.  

Michael Caligiuri, MD

President, City of Hope National Medical Center; Deana and Steve Campbell Physician-in-Chief

Michael Caligiuri, MD, is president of City of Hope National Medical Center, the Deana and Steve Campbell Physician-in-Chief Distinguished Chair of City of Hope. A renowned physician, scientist, builder, innovator, leader and visionary, Dr. Caligiuri is dedicated to developing the next generation of leading-edge cancer therapies, rapidly delivering them to patients and ultimately curing the disease. Prior to joining City of Hope, he was a physician, scientist and program leader in the cancer program at The Ohio State University. He served as CEO of The James Cancer Hospital and Solove Research Institute and he directed The Ohio State University Comprehensive Cancer Center for 14 years, recruiting over 300 cancer physicians and scientists. He has been recognized with myriad honors and awards throughout his career, including the Director’s Service Award and the MERIT Award and an Outstanding Investigator Award from the NCI, the John Wayne Clinical Research Award from the Society of Surgical Oncologists, and the Emil J Freireich Award in Clinical Cancer Research from The University of Texas MD Anderson Cancer Center. He is an elected fellow of the American Association for the Advancement of Science, the American College of Physicians, and the Alpha Omega Honor Medical Society, as well as an elected member of the Association of American Physicians and the American Society for Clinical Investigation. Dr. Caligiuri was elected to the National Academy of Medicine’s Class of 2018 for his outstanding professional achievements and commitment to service, including his breakthrough discoveries in natural killer cell (NK) leukemia and cutaneous T cell lymphoma. He is also the immediate past president of the American Association for Cancer Research, and he was also recently named a fellow of the AACR.

Yanin Chavarri Guerra, MD, MSc

Principal Investigator in Hemato-Oncology Department, Salvador Zubiran National Institute of Medical Sciences and Nutrition, Mexico City, Mexico

Yanin Chavarri-Guerra, MD, MSc, is a member of the faculty at the National Institute of Medical Sciences and Nutrition (INCMNSZ) in Mexico City,, where she is dedicated to the treatment of breast cancer patients. Following her clinical oncology fellowship at INCMNSZ she completed a fellowships in Breast Cancer Research at Massachusetts General Hospital, and a postdoctoral fellowship in Cancer Genetics at City of Hope in 2017. Dr. Chavarri is a Co-Investigator in the international study “Molecular Genetics Studies of Cancer Patients and Their Relatives¨ from City of Hope, and the Principal Investigator in several investigator-initiated basic and epidemiological studies. Her research focuses on disparities in access to cancer care in low and middle-income countries, particularly focused on breast cancer in Mexico. Currently, Dr. Chavarri-Guerra leads two investigator-initiated studies at INCMNSZ, including a patient navigation study to improve access to supportive care for patients with advanced cancer in Mexico City. She received the National Award for Research in Oncology from the Mexican Society of Oncology (2008), the International Development Award (2010) and the International Innovation Grant (2015) from the American Society of Clinical Oncology (ASCO) and the Conquer Cancer Foundation (CCF). She is currently a member of the National System of Investigators of the National Council of Science and Technology in Mexico (CONACYT) and of the System of Investigators of the National Institutes of Health of Mexico.

Fergus J. Couch, PhD

Professor

Fergus J. Couch, Ph.D. is a Professor and Chair of the Division of Experimental Pathology and Laboratory Medicine within the Department of Laboratory Medicine and Pathology at the Mayo Clinic. He holds joint appointments in the Departments of Health Sciences Research and Biochemistry and Molecular Biology. Dr. Couch works on the genetics of breast cancer, with over 300 publications relating to the discovery and clinical characterization of inherited genetic variants in cancer susceptibility genes. Dr. Couch is the principal investigator of the Mayo Clinic Breast Cancer Registry and is a founder and a member of the coordinating committee of CIMBA (the consortium of investigators of modifiers of BRCA1/2) that is focused on identifying genetic modifiers of breast cancer risk in the BRCA1 carrier population. Similarly, he is the principal investigator of the Triple Negative Breast Cancer Consortium (TNBCC), aimed at understanding the genetic etiology of triple negative breast cancer, and is a long-term contributor to the international Breast Cancer Association Consortium (BCAC). Dr. Couch is a co-founder of the Evidence-based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) consortium that is focused on establishing the clinical relevance of variants of uncertain significance (VUS) in BRCA1 and BRCA2. Within ENIGMA, he is coordinating the “Other Predisposition Gene Working Group” in an effort to characterize the risk and penetrance of deleterious mutations and VUS in non-BRCA1/2 predisposition genes. He has also collaborated with investigators from Memorial Sloan Kettering Cancer Center and the University of Pennsylvania to develop the Prospective Registry Of Multi-Plex Testing (PROMPT) for patients with mutations in predisposition genes. Finally, Dr. Couch is a founding member and participant in COMPLEXO, a consortium of investigators aiming to identify additional breast cancer predisposition genes.

David Duggan, Ph.D.

Technical Advisor to the Chief Operating Officer of the Translational Genomics Institute (TGen)

David Duggan, PhD, Technical Advisor to the Chief Operating Officer of the Translational Genomics Institute (TGen), is a leading translational genomics researcher and technical analyst with 28 years of scientific expertise and more than a decade of experience advising equity management firms on many of the leading genomics and personalized medicine companies. His discovery-based research and translational genomics interests are focused on the discovery and validation of novel genetic- and or genomic-based biomarkers for complex diseases, including cancer and translating clinically validated and useful findings to improve individual and population risk prediction, early detection, diagnostics, prognostics, and or therapeutic decision-making. With the use of state-of-the-art study designs and advanced genomic technologies, Dr. Duggan’s TGen laboratory has generated data on >300,000 study participants. His lab was among the first groups to propose GWAS studies and published one of the first polygenic risk score papers (Zheng et al., NEJM 2008). He has been an investigator on 26 NIH funded grants and a key member of numerous consortiums including NCI’s Colon Cancer Family Registry Consortium (CCFR), NCI’s Breast Cancer Family Registry (BCFR), NHGRI’s Population Architecture of Genomics and Epidemiology (PAGE), NCI’s Women’s Environmental, Cancer, and Radiation Epidemiology (WECARE), NCI’s Genetic Epidemiology of Colorectal Cancer Consortium (GECCO), and NCI’s International Consortium on Prostate Cancer Genetics (ICPCG). Dr. Duggan received his Ph.D. in human genetics from the University of Pittsburgh and obtained his post-doctoral training at the National Human Genome Research Institute, National Institutes of Health.

Judy Garber, MD, MPH

Director, Center for Cancer Genetics and Prevention

Dr. Garber is the Chief of the Division of Cancer Genetics and Prevention at Dana-Farber Cancer Institute and a Professor of Medicine at Harvard Medical School. Dr. Garber conducts research in clinical cancer genetics, with a special focus in the genetics of breast cancer.  She has played a major role in the development of national guidelines in cancer genetics. She is also a leader in research into the characteristics and treatment of triple negative or basal-like breast cancer, the most common form in women with BRCA1 mutations. Her translational research focuses on the evaluation of novel agents targeting DNA repair defects in breast cancer, including PARP inhibitors for treatment and prevention of breast cancer and other BRCA-associated cancers.

In 2011-2012, Dr. Garber was the President of American Association for Cancer Research (AACR), the largest organization of cancer researchers in the world. She is a member of the National Cancer Advisory Board and was elected into the National Academy of Medicine in 2013. She also serves as the Co-Scientific Director of the Breast Cancer Research Foundation and past chair of the Breast Cancer Research Foundation Scientific Advisory Board. She is an ASCO Statesman and a Fellow of the AACR Academy.

 

Veda Giri, MD

Associate Professor

Veda N. Giri, MD is an Associate Professor in Medical Oncology, Cancer Biology, and Urology at Sidney Kimmel Cancer Center at Thomas Jefferson University.  She is a medical oncologist with specialization in clinical cancer genetics.  Dr. Giri is Director of Cancer Risk Assessment and Clinical Cancer Genetics at Thomas Jefferson University, where she leads an integrated and comprehensive effort in inherited cancer risk assessment and conducts studies focused on genetic evaluation of cancer risk. She has focused interest in developing the field of genetic counseling and genetic testing for inherited prostate cancer.  Dr. Giri started the first Men’s Genetic Risk Clinic in the US in 2014 focused on genetic evaluation of inherited prostate cancer. Dr. Giri also co-chaired the first and second international consensus conference on developing a comprehensive framework and implementation for genetic evaluation of prostate cancer. Her research has contributed insights into the germline spectrum of men undergoing multigene testing for inherited prostate cancer, as well as insights into the needs of men undergoing genetic counseling. 

Dr. Giri received her medical degree from Jefferson Medical College (now Sidney Kimmel Medical College), and proceeded to complete her residency in Internal Medicine and fellowship in Hematology-Oncology at the University of Michigan.  She then completed advanced training in molecular cancer genetics at Fox Chase Cancer Center (FCCC).  From 2006-2014, she directed prostate cancer risk assessment at FCCC, developing studies focused on evaluating the role of genetic markers in prostate cancer risk assessment.  Dr. Giri has served on national committees including the National Comprehensive Cancer Network Prostate Cancer Early Detection Panel and NIH PDQ® Cancer Genetics Editorial Board, contributing expertise in cancer risk assessment and prostate cancer genetics.

 


Stacy W. Gray, MD

Associate Clinical Professor

Stacy Gray, MD, AM is an Associate Clinical Professor with a primary appointment in the Division of Clinical Cancer Genomics in the Department of Population Sciences and a secondary appointment in the Department of Medical Oncology and Therapeutics Research at City of Hope. Dr. Gray received her MD from the University of Chicago Pritzker School of Medicine. She completed her residency in Internal Medicine and her fellowship in Hematology/Oncology at The University of Chicago Hospitals. While in fellowship, she obtained a Masters degree in Public Policy from the University of Chicago Harris School, followed by a post-doctoral research fellowship in cancer communication at the University of Pennsylvania. In 2008, she joined the faculty of the Dana-Farber Cancer Institute, the Brigham and Women's Hospital and Harvard Medical School where she worked as a medical oncologist and cancer outcomes researcher in the division of Population Sciences and the Lowe Center for Thoracic Oncology. Dr. Gray’s research focuses on understanding the medical and psychosocial outcomes related to the use of genomic technologies in cancer care. One of her goals is to understand the relationships between information dissemination on an individual and population level, and the adoption of personalized cancer technologies. She also studies the clinical implementation of cancer whole-exome sequencing (WES), the "actionability" of sequence data in different populations, the integration of genomic data into the electronic health record and the social and behavioral science methods that can be used to answer emerging questions in cancer dissemination and implementation research. Her overall goal is to gain a better understanding of how a variety of factors may be working to drive the use of new genomic technologies and design targeted interventions to improve the delivery of precision cancer medicine. Dr. Gray serves on the ASCO Cancer Research Committee, holds multiple leadership roles in an NIH research consortium research funding and has been supported by the National Human Genome Research Institute, The agency of Healthcare Research and Quality, The American Cancer Society, The American Society of Clinical Oncology, and The Robert Wood Johnson Foundation.

Stephen B Gruber, M.P.H., MD, PhD,

Director of the Center of Precision Medicine at City of Hope Medical Center

Stephen Gruber, MD, PhD, MPH is Director of the Center of Precision Medicine at City of Hope Medical Center. Dr. Gruber is a board-certified medical oncologist, cancer geneticist and epidemiologist whose research focuses on genetic and environmental contributions to cancer. His particular research interests include the genetic epidemiology of cancer, with emphasis on colorectal cancer; the molecular pathogenesis of cancer, integrated with genetic epidemiology; methods in genetic and molecular epidemiology; and clinical cancer genetics and translational research in cancer prevention. He has received a number of honors and awards and is the author of  more than 158 peer-reviewed publications related to his work in the field of cancer genetics, particularly as it relates to colorectal cancer. In addition to serving on editorial boards for several professional journals, Dr. Gruber is active in national organizations. Since 2005, he has been Chair of the Colorectal Family Registries Advisory Panel for the National Cancer Institute and for the past three years chaired the Cancer Genetics Education Committee of the American Society of Clinical Oncology. Dr. Gruber obtained his Master of Public Health Degree from Yale University in 1986. After completing his Doctorate Degree in Epidemiology at Yale in 1988, he obtained his al Medical Degree from the University of Pennsylvania Medical School in 1992, where he also completed his internship and residency. He completed fellowships in medical oncology at Johns Hopkins Hospital and in clinical medical genetics at the University of Michigan.

Kent Hoskins, MD

Associate Professor of Medicine at the University of Illinois at Chicago

Kent Hoskins, MD is an Associate Professor of Medicine at the University of Illinois at Chicago where he is director of Cancer Genetics and co-Leader of the Breast Cancer Research Group in the University of Illinois Cancer Center.  He is a Medical Oncologist who specializes in the treatment of breast cancer and genetic evaluation of individuals with hereditary breast cancer risk. Early in his career he was part of a team at the University of Michigan and then at the University of Pennsylvania that was involved in efforts to clone the BRCA1 gene. . His work involves efforts to identify the biological underpinnings of the poor outcomes observed in African-American women with breast cancer. Currently his research focuses on developing a population health strategy for identifying individuals with hereditary cancer risk in the primary care setting, with an emphasis on health disparities.

Beth Y. Karlan, MD

Professor, Department of Obstetrics and Gynecology

Beth Y. Karlan, MD is nationally renowned leader in the diagnosis and treatment of women's reproductive cancers. She is referred complex and difficult cases from around the country. She is Director of Gynecologic Oncology at Cedars-Sinai Medical Center, and one of the four gynecologic oncologists heading the international referral and treatment program for Ovarian Cancer at the Cedars-Sinai Comprehensive Cancer Center. Dr. Karlan’s research focuses on ovarian cancer specific biomarkers for early detection, prognostication and targeted/individualized therapy, and inherited cancer susceptibility. She is a recipient of numerous awards and honors for excellence in the fields of cancer treatment and research. and has published over 80 articles, books and abstracts. She also serves as the Director of the Gilda Radner Ovarian Detection Program at Cedars-Sinai Medical Center. A noted speaker, Dr. Karlan has spoken as guest lecturer at medical centers and conventions throughout the world. She serves as an editorial consultant and reviewer for numerous cancer and obstetrics and gynecology journals, including the Journal of Women's Health and Gynecologic Oncology.

Seema A Khan, MD

Bluhm Family Professor of Cancer Research & Co-Leader, Cancer Prevention Program

Seema Khan, MD is co-Leader of the Cancer Prevention Program and a surgical oncologist. She has specific interest in biomarkers of breast cancer risk that can be identified in minimal samples of breast epithelium. Her research projects include investigation of RNA and microRNA biomarkers in benign biopsy material, that will serve to better stratify breast cancer risk, and as targets for specific prevention interventions. She has conducted early phase prevention trials, which currently focus on the evaluation of topical transdermal drug delivery to the breast. Her laboratory interests include the investigation of progesterone signaling in the breast, in the context of early events that relate to cancer prevention. She is the chair of a Phase III ECOG trial of local therapy for the intact primary tumor in women with Stage IV breast cancer (E2108), and of a Phase II trial testing the use of MRI and DCIS Score in women with DCIS.

Elisabeth King, MSN, RN, FNP-C, AGN-BC

Nurse Practitioner

Elisabeth King, RN, FNP, AOCNP, AGN is a nurse practitioner and the senior manager of Genomic Cancer Risk Counseling in the Division of Clinical Cancer Genomics at City of Hope. Ms. King joined City of Hope in 2018 from Texas Oncology, where she helped lead and support the Advanced Practice Provider and Genetics programs throughout the state. She is a family nurse practitioner and also holds advanced nursing certifications in oncology and genetics. She received her bachelor’s degree in biology with a focus on genetics and biotechnology from University of Texas at Austin. She earned her master’s degree in nursing at Frontier Nursing University. King is an alumnus and clinical faculty member of the City of Hope Intensive Course in Cancer Risk Assessment.

Bita Nehoray, MS, CGC

Genetic Counselor

Bita Nehoray, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree in Human Genetics and Genetic Counseling from Stanford University. Ms. Nehoray joined the City of Hope Division of Clinical Cancer Genomics in 2012, where she provides cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer, with a focus in Li-Fraumeni syndrome. She is fluent in Spanish and Farsi, and is committed to advancing the provision of cancer genetics services to medically underserved and culturally diverse populations. Other clinical responsibilities include providing pro-bono cancer genetic counseling services to underserved Latino families through an outreach program established by the Division of Clinical Cancer Genomics and supported through government and foundations grants and compassionate funding. Current research projects include understanding cancer risk, penetrance, prevalence, and clinical outcomes for individuals with TP53 mutations as part of the LiFT Up study, evaluating the spectrum of germline variants in Israeli breast cancer patients, and assessing Community-based provider experiences with polygenic risk scores in genetic cancer risk assessment. Her past research included assessing the influence of pre-consultative interventions in the uptake of genetic counseling services in Latinas. She also serves on the Genetic Counseling Advisory Committee for the Li-Fraumeni Syndrome Association. She is an active member of the National Society of Genetic Counselors, Southern California genetic counselors, and the American Society of Human Genetics.

Olufunmilayo I. Olopade, MD, FACP

Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics

Olufunmilayo Falusi Olopade, MD, FACP, OON is the Walter L. Palmer Distinguished Service Professor of Medicine and Human Genetics and founding director of the Center for Clinical Cancer Genetics at the University of Chicago Medicine. She is an expert in cancer risk assessment and individualized treatment for the most aggressive forms of breast cancer, having developed novel management strategies based on an understanding of the altered genes in individual patients. She stresses comprehensive risk reducing strategies and prevention in high-risk populations, as well as earlier detection through advanced imaging technologies. Dr. Olopade has received numerous honors and awards, including honorary degrees from North Central, Dominican, Bowdoin and Princeton universities. She is also a recipient of the Doris Duke Distinguished Clinical Scientist and Exceptional Mentor Award, an American Cancer Society Clinical Research Professorship, a MacArthur Foundation "Genius" Fellowship and Officer of the Order of the Niger Award. Dr. Olopade is an elected member of the American Academy of Arts and Sciences and the American Philosophical Society. She currently serves on the board of directors for the American Board of Internal Medicine, the National Cancer Advisory Board, Susan G. Komen for the Cure, Cancer IQ and the Lyric Opera of Chicago.

Colin Pritchard, MD, PhD

Assistant Professor

Dr. Pritchard is an Assistant Professor of Laboratory Medicine, as well as the associate director of the genetics and solid tumors laboratory at the University of Washington Medical Center that services the Seattle Cancer Care Alliance (SCCA) that includes Seattle Children’s hospital. Dr. Pritchard undertook his undergraduate and graduate training at the University of Washington in Seattle in the United States. He completed his medical training at the University of Washington School of Medicine. The Pritchard laboratory focuses on oncology molecular diagnostics, particularly the source and utility of cell-free nucleic acid biomarkers in blood, and the development of innovative molecular diagnostics for the identification of mutations that can guide therapeutic decision-making. His clinical work focuses on applications of next-generation sequencing gene panels for cancer risk assessment and precision treatment. He has led the development and implementation of the ColoSeq™ Lynch and Polyposis Syndrome Panel and UW-OncoPlex™ Cancer Gene Panel in current clinical use for cancer patients and their families.

Mark E. Robson, MD

Clinic Director

Mark Robson, MD is Chief of the Breast Medicine Service in the Department of Medicine at Memorial Hospital in New York, an attending physician on Breast Medicine and Clinical Genetics Services, and a member of the Memorial Sloan Kettering Cancer Center. His clinical research has concentrated on the optimal application of germline information to the management of cancer patients, particularly those with breast cancer. He has been a lead investigator for a number of trials of PARP inhibitors in patients with BRCA associated breast cancer. He is currently developing new models for the acquisition of germline information, including "mainstreaming" through test ordering by primary oncology providers and broad genomic screening in the context of somatic mutation profiling. He is also investigating the use of polygenic risk scores in facilitating decision-making among women with or without an inherited predisposition. Dr. Robson serves on the editorial board of the Journal of Clinical Oncology and is an associate editor for the Journal of the National Cancer Institute and Genetics in Medicine. He is also the past chair of the Ethics Committee of the American Society of Clinical Oncology and has served several terms on the ASCO Cancer Prevention Committee and its Cancer Genetics subcommittee. Dr. Robson graduated from the University of Virginia School of Medicine in Charlottesville, Virginia, and did his internal medicine residency and hematology-oncology fellowship training at Walter Reed Army Medical Center in Washington DC.

Iris Romero, MD, MS

Associate Professor and research scientist in the Department of Obstetrics & Gynecology

Iris Romero, MD, MS is an Associate Professor and research scientist in the Department of Obstetrics & Gynecology and the Dean for Diversity and Inclusion for the Biological Sciences Division of the University of Chicago.  Since joining the faculty in 2007, Dr. Romero has successfully merged a career in cancer biology with clinical application to provide cutting edge, quality healthcare for women.  Her clinical practice is focused on hereditary breast and ovarian cancer, and includes care for women with genetic predisposition for cancer and general obstetrics and gynecology. She also has a translational research lab aimed at identifying agents, like metformin, that can be repurposed to target the ovarian cancer tumor microenvironment. She has received NIH funding through the national Reproductive Scientist Development Program. Her research has been published in top scientific journals including Nature, Obstetrics & Gynecology, American Journal of Obstetrics and Gynecology, and Gynecologic Oncology. Dr. Romero attended University of New Mexico for medical school and completed OB/Gyn residency at University of Utah and she completed training in hereditary cancer genetics through the City of Hope.

Thomas Slavin, MD, FACMG, DABMD

Vice President of Medical Affairs for Oncology

Dr. Slavin is Senior VicePresident of Medical Affairs for Oncology at Myriad Genetics. He is aphysician-scientist, triple-board-certified in clinical genetics, moleculardiagnostics and pediatrics.  Most recently, he served as assistantprofessor in the departments of Medical Oncology & Therapeutics Researchand Population Sciences at City of Hope National Medical Center. Dr. Slavingraduated medical school with Alpha-Omega-Alpha-honors from the University ofSouth Florida. He completed his residency programs at Case Western Reserve inCleveland, Ohio; this training included a postdoctoral research year ingenetic epidemiology. He has also completed graduate course work towards aMasters degree in clinical research through the University of SouthernCalifornia. He is an active member of the American Association of CancerResearch, the American Society of Clinical Oncology (ASCO), the AmericanSociety of Human Genetics, the Collaborative Group of the Americas on InheritedColorectal Cancer, and is a fellow of the American College of Medical Geneticsand Genomics. He has served on National Comprehensive Cancer Network (NCCN)committees for both the genetics of and screening for colorectal cancer. He hasserved on three ClinGen expert working group committees for variantclassification of breast, gastrointestinal and ovarian cancer predispositiongenes.  Focused on expanding genetics education for cancer care providers,Dr. Slavin has helped shape both ASCO University as well as City of Hope’shereditary genomics training program. He is a well-published researcher in thefield of medical genetics, including over 60 journal articles, multiple bookchapters, and numerous presentations at national and international medicalmeetings. He has been involved in many national cancer research grants, and wasa 2018 National Institutes of Health (NIH) K08-career development grantawardee. 

Jeffrey Weitzel, MD

Professor of Oncology and Population Sciences

Jeffrey N. Weitzel, MD is Founder of the Division of Clinical Cancer Genomics and the Cancer Screening & Prevention Program at City of Hope Comprehensive Cancer Center in Duarte, California.  Board Certified in Clinical Genetics and Medical Oncology, Dr. Weitzel is a Professor of Oncology and Population Sciences at City of Hope, and holder of the Dr. Norman and Melinda Payson Professorship in Medical Oncology.  He is also the ASCO Conquer Cancer Research Professor in Breast Cancer Disparities.  At the vanguard of precision prevention, Dr. Weitzel’s multidisciplinary clinical, research, and training programs emphasize translational research in cancer disparities, genomic cancer risk assessment, chemoprevention, targeted therapy, clinical and psychosocial outcomes, genetic epidemiology and health services research, with a focus on underserved populations. He is member of the NCCN Genetics/Familial Risk Assessment practice guidelines committee. Dr. Weitzel is the principal investigator for the Clinical Cancer Genomics Community Research Network and Medical Director for the Cancer Genomics Education Program, which are funded in part by the National Cancer Institute. Along with Dr. Blazer, he received the 2019 American Society of Human Genetics Arno Motulsky-Barton Childs Award for Excellence in Human Genetics Education.

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Roundup 1: Updates on Cancer Genes & Syndromes
Open to view video.
Open to view video. 00:00 - 07:50 Welcome to Frontiers and Pioneers, Genomics and Precision Medicine --- 07:50 - 40:06 Keynote Address 1: Penetrance of Moderate Risk Genes: The CARRIERS Project - Fergus Couch, PhD --- 40:06 - 49:45 ATM, CHEK2, PALB2 - Thomas Slavin, MD, FACMG, DABMD --- 49:45 - 01:04:44 PMS2, POLE, POLD1, NTHL1 - Stephen Gruber, MD, PhD, MPH --- 01:04:44 - 01:17:12 Germline EGFR - Stacy Gray, MD, AM --- 01:17:12 - 01:31:12 TP53: Genotypes, Phenotypes and the Evolving Clinical Picture - Judy Garber, MD, MPH --- 01:31:12 - 01:49:11 Discussion/ Q&A --- 01:49:11 - 01:56:30 ORIEN and the City of Hope Precision Medicine Program - Michael Caligiuri, MD
Roundup 2: Complex Results and Variant Classifications
Open to view video.
Open to view video. 01:19 - 24:38 Keynote Address 2: Questions for the Lab Director: How'd You Make That Call? - Colin Pritchard, MD, PhD --- 24:38 - 39:43 Making Sense of MIssense: Pheno; Functional; Multifactorial Models - Fergus Couch, PhD --- 39:43 - 51:45 The Challenge of Somatic Inference and Clonal Hematopoiesis - Jeffrey Weitzel, MD --- 51:45 - 01:03:29 Navigating and Managing Cases with Complex Results - Bita Nehoray, MD, LCGC --- 01:03:29 - 01:25:11 Discussion/ Q&A
Roundup 3: Updates on Precision Management and the Prevention-focused Practice Part 1
Open to view video.
Open to view video. 00:00 - 34:38 Keynote Address 3: Updates on Managing Hereditary Breast Ovarian Cancer - Judy Garber, MD, MPH --- 34:38 - 59:41 Genetic Testing for Inherited Prostate Cancer: Considerations for Patients and Providers - Veda Giri, MD --- 59:41 - 01:12:13 Gastrointestinal Cancer Genes and Precision Medicine - Stephen Gruber, MD, PhD, MPH --- 01:12:13 - 01:26:28 Discussion/ Q&A
Roundup 4: Rustling Polygenic Risk Scores (PRS) out of Genome-wide Association Studies
Open to view video.
Open to view video. 00:00 - 32:00 Keynote Address 4: The Science Behind Polygenic Risk Scores - Breast and Ovarian Cancer Risk and Boadicea - Antonis Antonious, PhD --- 32:00 - 45:36 Polygenic Risk Scores in Gastrointestinal Cancers - David Duggan, PhD 45:36 - 01:11:40 Keynote Address 5: Assessing the Clinical Utility of Genetic Risk Assessment 01:11:40 - 01:53:54 Discussion/ Q&A
Roundup 5: The New Frontier: Genomics for More People and More People Delivering Genomics Part 1
Open to view video.
Open to view video. 00:00 - 31:00 Keynote Address 6: Exceptionalism to Exceptional Care: The End of Exceptionalism - Leslie Biesecker, MD --- 31:00 - 39:27 BFOR: Toward Population-based Genetic Testing for Cancer Risk - Beth Karlan, MD --- 39:27 - 50:15 "The New 40": Prevalence of Genetic Predisposition Among Older Patients with Breast Cancer - Yanin Chavarri-Guerra, MD, MSc --- 50:15 - 01:06:55 Direct-to-Consumer Genetic Testing: What Does it Mean to Your Patients and Your Practice? - Kathleen Blazer, EdD, MS, LCGC --- 01:06:55 - 01:26:23 Leveraging the Workforce Through Alternate GCRA Delivery Models - Kent Hoskins, MD --- 01:26:23 - 01:54:47 Discussion/ Q&A
Roundup 6: The New Frontier: Genomics for More People and More People Delivering Genomics Part 2
Open to view video.
Open to view video. 00:00 - 17:29 Germline in Tumors: Traceback Approaches to Family Informative Testing (FIT) - Jeffrey Weitzel, MD --- 17:29 - 28:54 Cell-free DNA to identify Germline Carriers and As a Potential Surveillance Tool - Thomas Slavin, MD, FACMG, DABMD --- 28:54 - 40:46 Paired Germline/ Tumor Analysis in GI Cancers - Colin Pritchard, MD, PhD --- 40:46 - 56:00 Systems for Delivering and Understanding Genomic Information - Stacy Gray, MD, AM--- 56:00 - 01:19:32 Discussion/ Q&A
Roundup 7: Updates on Management in the Prevention-focused Practice Part 2
Open to view video.
Open to view video. 00:00 - 28:54 Keynote Address 7: Understanding And Managing Hereditary Gynecologic Cancer Risk - Beth Karlan, MD --- 28:54 - 01:02:40 Outcomes and Retention of Higher Risk Patients Receiving MRI Surveillance - Olufunmilayo Olopade, MD, FACP, OON --- 01:02:40 - 01:22:01 Modifying Risk: Hormones, Chemoprevention and Lifestyle Interventions - Seema Khan, MD --- 01:22:01 - 01:44:27 Discussion/ Q&A
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