Review Bundle 02 2023
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Instruction |
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Time |
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Tasks |
The Fundamentals of GCRA
- Describe fundamentals of the genetic cancer risk assessment (GCRA) process.
- Take a comprehensive cancer family history.
- Explain the importance of and strategies for confirming key cancers.
- Identify sporadic, familial, and hereditary cancer patterns.
Documenting the Cancer Family History
- Recognize the importance of eliciting, documenting and verifying the patient family history.
- Collect family history information, focusing on details and questions relevant to cancer history documentation.
- Identify questionable or incomplete information that will need further verification to assess cancer risk in the family.
- Draw a 3-4 generation pedigree using standard pedigree nomenclature and symbols.
- Demonstrate skills associated with proficiency in collecting and documenting the family history of cancers.
Reading the Pathology Report through the Genomics Lens
- Apply reading and interpreting pathology reports to define cancer stage and extract information on histology/molecular features.
- Describe the roles of other diagnostic data (imaging, CT scans, blood markers).
Laboratory Methods for Inherited Cancer Susceptibilities
- Identify the methods, benefits, and limitations of different types of NGS cancer panels.
- Recognize approaches to variant interpretation and reporting.
- Apply different types of genetic tests to clinical vignettes.
Characterization and Clinical Interpretation of Germline Genomic Variants
- Review types of genetic variants.
- Outline the categories of variant classification established by the ACMG.
- Describe the methods, resources, and tools used to classify variants.
- Discuss approaches to re-classifying variants of uncertain significance (VUS).
Mutation Nomenclature: Reading and Interpreting Genetic Test Results
- Recognize and describe various types of mutations.
- Distinguish between different types of mutation nomenclature.
- Interpret a genetic test report
The modules in this bundle will discuss possible barriers and biases which may impact patient care (i.e., race, ethnicity, language, gender identity/orientation, age, socioeconomic status, attitudes, feelings, or other characteristics).
Accreditation Details for Bundle 2:
TARGET AUDIENCE: Physicians, Physician Assistants, Genetic Counselors, Master's or PhD in Genetics or Advanced Practice Nurses, and Geneticists.
ACCREDITATION STATEMENT: City of Hope is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.
CREDIT DESIGNATION: City of Hope designates this enduring material for a maximum of 4.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
The following credit type(s) are being offered for this course:
• AMA PRA Category 1 Credit™ 4.75
The following may apply AMA PRA Category 1 Credit™ for license renewal:
Registered Nurses: Nurses may report up to 4.75 credit hours toward the continuing education requirements for license renewal by their state Board of Registered Nurses (BRN). AMA PRA Category 1 Credit™ may be noted on the license renewal application in lieu of a BRN provider number.
Physician Assistants: The National Commission on Certification of Physicians Assistants states that AMA PRA Category 1 Credit™ accredited courses are acceptable for CME requirements for recertification.
Bita Nehoray, MS, CGC
Manager, Genetic Counselor
City of Hope
Bita Nehoray, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree in Human Genetics and Genetic Counseling from Stanford University. Ms. Nehoray joined the City of Hope Division of Clinical Cancer Genomics in 2012, where she provides cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer, with a focus in Li-Fraumeni syndrome and clonal hematopoiesis of indeterminate potential. Current research projects include understanding cancer risk, penetrance, prevalence, and clinical outcomes for individuals with TP53 pathogenic variants as part of the LiFT UP study, evaluating the use of whole body MRI and liquid biopsy for early cancer detection, chatbot use for disclosure of germline genetic test results, and assessing community-based provider experiences with TP53 results on germline testing. She also serves on the genetic counseling advisory committee for the Li-Fraumeni Syndrome Association, the ClinGen TP53 Variant Curation Expert Panel, and the California Advisory Council for Sharsheret. She is faculty for the City of Hope Intensive Course in Genetic Cancer Risk Assessment. She is an active member of the National Society of Genetic Counselors and Southern California Genetic Counselors.
Sandra Dreike, MS, CGC
Manager, Genetic Counselor
City of Hope
SANDRA DREIKE, MS, CGC is a licensed board-certified genetic counselor who specializes in cancer genetics. Sandra joined the City of Hope Division of Clinical Cancer Genomics in 2019, where she provides genetic counseling and cancer genetic risk assessments as a Senior Genetic Counselor. She received her Master of Science degree is Genetic Counseling from University of California, Irvine and her bachelor’s degree in Biology from California Polytechnic State University, San Luis Obispo. She previously practiced as a genetic counselor in Honolulu, HI where she specialized in cancer genetics and general pediatric and adult genetics. In addition to patient care she is a faculty member of the City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice, and research. Sandra is a member of the National Society of Genetic Counselors (NSGC) and Southern California Genetic Counselors (SCGC).
Madeline Currey
Clinical Research Associate
City of Hope
Madeline Currey is a clinical research associate in the Gray lab. She received a bachelor’s degree in biology from California State University Los Angeles, where she completed her undergraduate thesis in plant hydraulics and evolution. She joined the Gray lab in 2020, after a formative internship in the Division of Clinical Cancer Genomics. As an aspiring genetic counselor, she considers it an honor to be involved in research that increases the access and delivery of genetic services.
Colin Pritchard, MD, PhD
Assistant Professor
University of Washington
COLIN PRITCHARD, MD, PhD, is a Professor of Laboratory Medicine and Pathology at the University of Washington and Program Director for Cancer Precision Diagnostics for the Brotman Baty Institute for Precision Medicine. He also serves as the Co-Director of the Genetics and Solid Tumors Laboratory that services the Fred Hutchinson Cancer Center. The Pritchard laboratory focuses on oncology molecular diagnostics, particularly the source and utility of cell-free nucleic acid biomarkers in blood, and the development of innovative molecular diagnostics for the identification of DNA repair gene mutations that can guide therapeutic decision-making. His clinical work focuses on applications of next-generation sequencing gene panels for cancer risk assessment and precision treatment. He has led the development and implementation of the ColoSeq™ Lynch and Polyposis Syndrome Panel and the UW-OncoPlex™ Cancer Gene Panel in current clinical use for cancer patients and their families. He is a longstanding distinguished faculty member of the City of Hope Clinical Cancer Genomics Community of Practice. In 2021 Dr. Pritchard was awarded the C2 Catalyst for Precision Medicine Award from Scientific American.
Danielle Castillo, BS
Senior Research Associate
Danielle Castillo, BS, is a Senior Research Associate in the Department of Clinical Cancer Genetics Molecular Laboratory at the City of Hope, where she assists Mr. Herzog in the maintenance of the Breast Cancer Registry, Hispanic Mutation Project, LiFTUP Project and other research endeavors. After spending a good part of her senior year working on water conservation at Stellenbosch University in Cape Town, South Africa Mrs. Castillo graduated with a bachelor’s degree in biology from Whittier College in 2008 Mrs. Castillo worked as a biologist for Irvine Scientific before coming to the City of Hope in early 2009.