Review Bundle 02 2023

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Instruction
7 Learning Modules &
1 Micro Learning

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Time
6.00 Hours

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Tasks
6 Quizzes


The Fundamentals of GCRA

  • Describe fundamentals of the genetic cancer risk assessment (GCRA) process.
  • Take a comprehensive cancer family history.
  • Explain the importance of and strategies for confirming key cancers.
  • Identify sporadic, familial, and hereditary cancer patterns.

Documenting the Cancer Family History

  • Recognize the importance of eliciting, documenting and verifying the patient family history.
  • Collect family history information, focusing on details and questions relevant to cancer history documentation.
  • Identify questionable or incomplete information that will need further verification to assess cancer risk in the family.
  • Draw a 3-4 generation pedigree using standard pedigree nomenclature and symbols.
  • Demonstrate skills associated with proficiency in collecting and documenting the family history of cancers.

Reading the Pathology Report through the Genomics Lens

  • Apply reading and interpreting pathology reports to define cancer stage and extract information on histology/molecular features.
  • Describe the roles of other diagnostic data (imaging, CT scans, blood markers).

Laboratory Methods for Inherited Cancer Susceptibilities

  • Identify the methods, benefits, and limitations of different types of NGS cancer panels.
  • Recognize approaches to variant interpretation and reporting.
  • Apply different types of genetic tests to clinical vignettes.

Characterization and Clinical Interpretation of Germline Genomic Variants

  • Review types of genetic variants.
  • Outline the categories of variant classification established by the ACMG.
  • Describe the methods, resources, and tools used to classify variants.
  • Discuss approaches to re-classifying variants of uncertain significance (VUS).

Mutation Nomenclature: Reading and Interpreting Genetic Test Results

  • Recognize and describe various types of mutations.
  • Distinguish between different types of mutation nomenclature.
  • Interpret a genetic test report

The modules in this bundle will discuss possible barriers and biases which may impact patient care (i.e., race, ethnicity, language, gender identity/orientation, age, socioeconomic status, attitudes, feelings, or other characteristics).


Accreditation Details for Bundle 2:

TARGET AUDIENCE: Physicians, Physician Assistants, Genetic Counselors, Master's or PhD in Genetics or Advanced Practice Nurses, and  Geneticists.

ACCREDITATION STATEMENT: City of Hope is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

CREDIT DESIGNATION: City of Hope designates this enduring material for a maximum of 4.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

The following credit type(s) are being offered for this course:

•  AMA PRA Category 1 Credit™  4.75 

The following may apply AMA PRA Category 1 Credit™ for license renewal:

Registered Nurses: Nurses may report up to 4.75 credit hours toward the continuing education requirements for license renewal by their state Board of Registered Nurses (BRN). AMA PRA Category 1 Credit™ may be noted on the license renewal application in lieu of a BRN provider number.

Physician Assistants: The National Commission on Certification of Physicians Assistants states that AMA PRA Category 1 Credit™ accredited courses are acceptable for CME requirements for recertification.


Bita Nehoray, MS, CGC

Manager, Genetic Counselor

City of Hope

Bita Nehoray, MS, CGC, is a licensed board-certified genetic counselor specializing in cancer genetics. She received her Master’s degree in Human Genetics and Genetic Counseling from Stanford University. Ms. Nehoray joined the City of Hope Division of Clinical Cancer Genomics in 2012, where she provides cancer genetics services for patients and families suspected to have a hereditary predisposition to cancer, with a focus in Li-Fraumeni syndrome and clonal hematopoiesis of indeterminate potential. Current research projects include understanding cancer risk, penetrance, prevalence, and clinical outcomes for individuals with TP53 pathogenic variants as part of the LiFT UP study, evaluating the use of whole body MRI and liquid biopsy for early cancer detection, chatbot use for disclosure of germline genetic test results, and assessing community-based provider experiences with TP53 results on germline testing. She also serves on the genetic counseling advisory committee for the Li-Fraumeni Syndrome Association, the ClinGen TP53 Variant Curation Expert Panel, and the California Advisory Council for Sharsheret. She is faculty for the City of Hope Intensive Course in Genetic Cancer Risk Assessment. She is an active member of the National Society of Genetic Counselors and Southern California Genetic Counselors.

Sandra Dreike, MS, CGC

Manager, Genetic Counselor

City of Hope

SANDRA DREIKE, MS, CGC is a licensed board-certified genetic counselor who specializes in cancer genetics. Sandra joined the City of Hope Division of Clinical Cancer Genomics in 2019, where she provides genetic counseling and cancer genetic risk assessments as a Senior Genetic Counselor. She received her Master of Science degree is Genetic Counseling from University of California, Irvine and her bachelor’s degree in Biology from California Polytechnic State University, San Luis Obispo. She previously practiced as a genetic counselor in Honolulu, HI where she specialized in cancer genetics and general pediatric and adult genetics. In addition to patient care she is a faculty member of the City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice, and research. Sandra is a member of the National Society of Genetic Counselors (NSGC) and Southern California Genetic Counselors (SCGC).

Madeline Currey

Clinical Research Associate

City of Hope

Madeline Currey is a clinical research associate in the Gray lab. She received a bachelor’s degree in biology from California State University Los Angeles, where she completed her undergraduate thesis in plant hydraulics and evolution. She joined the Gray lab in 2020, after a formative internship in the Division of Clinical Cancer Genomics. As an aspiring genetic counselor, she considers it an honor to be involved in research that increases the access and delivery of genetic services.

Colin Pritchard, MD, PhD

Assistant Professor

University of Washington

COLIN PRITCHARD, MD, PhD, is a Professor of Laboratory Medicine and Pathology at the University of Washington and Program Director for Cancer Precision Diagnostics for the Brotman Baty Institute for Precision Medicine. He also serves as the Co-Director of the Genetics and Solid Tumors Laboratory that services the Fred Hutchinson Cancer Center. The Pritchard laboratory focuses on oncology molecular diagnostics, particularly the source and utility of cell-free nucleic acid biomarkers in blood, and the development of innovative molecular diagnostics for the identification of DNA repair gene mutations that can guide therapeutic decision-making. His clinical work focuses on applications of next-generation sequencing gene panels for cancer risk assessment and precision treatment. He has led the development and implementation of the ColoSeq™ Lynch and Polyposis Syndrome Panel and the UW-OncoPlex™ Cancer Gene Panel in current clinical use for cancer patients and their families. He is a longstanding distinguished faculty member of the City of Hope Clinical Cancer Genomics Community of Practice. In 2021 Dr. Pritchard was awarded the C2 Catalyst for Precision Medicine Award from Scientific American.

Danielle Castillo, BS

Senior Research Associate

Danielle Castillo, BS, is a Senior Research Associate in the Department of Clinical Cancer Genetics Molecular Laboratory at the City of Hope, where she assists Mr. Herzog in the maintenance of the Breast Cancer Registry, Hispanic Mutation Project, LiFTUP Project and other research endeavors. After spending a good part of her senior year working on water conservation at Stellenbosch University in Cape Town, South Africa Mrs. Castillo graduated with a bachelor’s degree in biology from Whittier College in 2008 Mrs. Castillo worked as a biologist for Irvine Scientific before coming to the City of Hope in early 2009.

Key:

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Cultural Linguistic Competency (CLC) & Implicit Bias (IB)
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The Fundamentals of GCRA
Open to view video.  |  57 minutes
Open to view video.  |  57 minutes Describe fundamentals of the genetic cancer risk assessment (GCRA) process. Take a comprehensive cancer family history. Explain the importance of and strategies for confirming key cancers. Identify sporadic, familial, and hereditary cancer patterns.
Review Quiz 02A
3 Questions  |  3 attempts  |  3/3 points to pass
3 Questions  |  3 attempts  |  3/3 points to pass Quiz for review of The Fundamentals of GCRA
Documenting the Family Cancer History
Open to view video.  |  12 minutes
Open to view video.  |  12 minutes Recognize the importance of eliciting, documenting and verifying the patient family history. Collect family history information, focusing on details and questions relevant to cancer history documentation. Identify questionable or incomplete information that will need further verification to assess cancer risk in the family. Draw a 3-4 generation pedigree using standard pedigree nomenclature and symbols. Demonstrate skills associated with proficiency in collecting and documenting the family history of cancers.
Review Quiz 02B
3 Questions  |  3 attempts  |  5/5 points to pass
3 Questions  |  3 attempts  |  5/5 points to pass Quiz for review of Documenting the Family Cancer History
Reading the Pathology Report Through a Genomics Lens
Open to view video.  |  35 minutes
Open to view video.  |  35 minutes Apply reading and interpreting pathology reports to define cancer stage and extract information on histology/molecular features. Describe the roles of other diagnostic data (imaging, CT scans, blood markers).
Review Quiz 02C
2 Questions  |  3 attempts  |  5/6 points to pass
2 Questions  |  3 attempts  |  5/6 points to pass Quiz for review of Reading the Pathology Report through the Genomic Lens
Laboratory Methods for Inherited Cancer Susceptibilities
Open to view video.  |  57 minutes
Open to view video.  |  57 minutes Identify the methods, benefits, and limitations of different types of NGS cancer panels. Recognize approaches to variant interpretation and reporting. Apply different types of genetic tests to clinical vignettes.
Review Quiz 02D
4 Questions  |  3 attempts  |  8/9 points to pass
4 Questions  |  3 attempts  |  8/9 points to pass Quiz for review of Laboratory Methods for Inherited Cancer Susceptibilities
Characterization and Clinical Interpretation of Germline Genomic Variants - Part 1
Open to view video.  |  62 minutes
Open to view video.  |  62 minutes Review types of genetic variants. Outline the categories of variant classification established by the ACMG. Describe the methods, resources, and tools used to classify variants. Discuss approaches to re-classifying variants of uncertain significance (VUS).
Characterization and Clinical Interpretation of Germline Genomic Variants - Part 2
Open to view video.  |  20 minutes
Open to view video.  |  20 minutes Review types of genetic variants. Outline the categories of variant classification established by the ACMG. Describe the methods, resources, and tools used to classify variants. Discuss approaches to re-classifying variants of uncertain significance (VUS).
Review Quiz 02E
2 Questions  |  3 attempts  |  2/2 points to pass
2 Questions  |  3 attempts  |  2/2 points to pass Quiz for review of Characterization and Clinical Interpretation of Germline Genomic Variants
Mutation Nomenclature: Reading and Interpreting Genetic Test Results
Open to view video.  |  45 minutes
Open to view video.  |  45 minutes Recognize and describe various types of mutations. Distinguish between different types of mutation nomenclature. Interpret a genetic test report.
Review Quiz 02F
5 Questions  |  3 attempts  |  4/5 points to pass
5 Questions  |  3 attempts  |  4/5 points to pass Quiz for review of Mutation Nomenclature: Reading and Interpreting Genetic Testing Results
Learning Evaluation and CME Code
Review Bundle 02 - Distance Learning Evaluation
21 Questions
21 Questions Please respond to the statements in this evaluation as they relate to your experiences with this review bundle. This survey will take less than 3 minutes to complete. This survey should be completed AFTER you have viewed all items in this module.
Review Bundle 02 Completion
No credits available  |  Certificate available
No credits available  |  Certificate available
Elective Modules
Micro Learning: Navigating a VUS
Open to view video.  |  20 minutes
Open to view video.  |  20 minutes Optional elective
Variant Nomenclature: Reading and Interpreting Genetic Test Results
Open to view video.  |  60 minutes
Open to view video.  |  60 minutes Recognize various types of genetic variants Distinguish between different types of variant nomenclature Interpret a genetic test report