Bundle 06 (2024)

Enrollment for this course is now closed, and its accreditation has ended.

Enroll in the current and accredited iteration of the COH/VA course if you would like to earn credit and a certificate of completion.

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Instruction
4 Learning Modules &
3 Elective Modules

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Time
5.00 Hours

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Tasks
4 Quizzes &
1 Case Scenario Assignment

Hereditary Gastrointestinal Cancer Syndromes, Part 1: Lynch Syndrome

Objectives

  • Recognize the features of hereditary gastrointestinal and other cancers associated with Lynch Syndrome.
  • Discuss the methods and limitations of tumor screening for Lynch syndrome.
  • Identify the features and mode of inheritance of Constitutional Mismatch Repair Deficiency (CMMRD).
  • Recognize the characteristics of Familial Colorectal Cancer (CRC) Type X.

Significance and Practical Applications for Tumor Phenotyping (IHC/MSI) in Hereditary Cancer Risk Assessment

Objectives

  • Determine which cases of CRC have defective mismatch repair.
  • Screen for Lynch Syndrome among newly diagnosed CRC & endometrial cancer (EC) patients.
  • Discuss Ohio State University clinical experience doing IHC on all newly diagnosed CRC & EC patients.
  • Review evaluation of genomic applications in practice and prevention (EGAPP) recommendations.

Hereditary Gastrointestinal Cancer Syndromes, Part 2: Polyposis

Objectives

  • Identify the features distinguishing different hereditary polyposis syndromes.
  • Recognize the association between polyp histology and potential germline genetic predisposition to a polyposis syndrome.
  • Discern the features of different polyposis syndromes, including: Familial adenomatous polyposis; MutYH-associated polyposis; Hamartomatous polyposis syndromes; Serrated polyposis syndrome.

Hereditary Gastrointestinal Cancer Syndromes, Part 3: Gastric Pancreatic

Objectives

  • Recognize the features of hereditary gastric cancers.
  • Recognize the features of hereditary pancreatic cancers.
  • Apply appropriate germline genetic testing strategies for hereditary gastrointestinal syndromes.

Sonia S. Kupfer, MD

Assistant Professor of Medicine

University of Chicago Medical Center

Sonia S. Kupfer is an Assistant Professor of Medicine in the Section of Gastroenterology at the University of Chicago Medical Center, Chicago, IL. She is the Director of the Gastrointestinal Cancer Risk and Prevention Clinic and co-Director of the Comprehensive Cancer Risk and Prevention clinic at the University of Chicago. She is funded by a K08 career development award from the NIH/NCI to study colorectal cancer genetic susceptibility variants in African Americans. Dr. Kupfer is also currently investigating genetics related to chemopreventive agents for colorectal cancer, notably vitamin D. In addition to her translational research, Dr. Kupfer is actively engaged in clinical studies in high-risk colorectal cancer primarily Lynch syndrome. Her clinical work focuses on hereditary GI cancer evaluation, testing and management. She also has served as co-Director of two CME conferences on genomics. Dr. Kupfer received her undergraduate degree from Yale University and then completed medical school, residency, chief residency and gastroenterology fellowship training at the University of Chicago. She is originally from a northern suburb of Chicago and currently resides in the Hyde Park area with her husband, an art dealer, and her two children.

Heather Hampel, MS, CGC

Associate Director, Division of Clinical Cancer Genomics

City of Hope

HEATHER HAMPEL, MS, CGC, is a Professor in the Department of Medical Oncology and Therapeutics Research and Associate Director of the Division of Cancer Genomics at City of Hope National Cancer Center. She co-leads the administration of more than 20 genetic counselors, 6 GCAs, and additional support staff who provide genetic cancer risk assessment through the City of Hope enterprise and more than 20 CRAs, LVNs and CRNs on the Precision Medicine consent team. Her research focuses on Lynch syndrome and universal tumor screening for Lynch syndrome. She has >190 publications on the prevalence of Lynch syndrome among colorectal and endometrial cancer patients, the best testing protocols, cost-effectiveness, and referral guidelines for cancer genetics. She was on the Board of Directors for the American Board of Genetic Counseling from 2006-2011, serving as President in 2009 and 2010. She has been on the Steering Committee of the National Colorectal Cancer Roundtable since 2016. She was on the Council of the Collaborative Group of the Americas on Inherited Colorectal Cancer from 2016-2019, serving as president in 2017-2018. She served as the Secretary/Treasurer of the National Society of Genetic Counselors in 2022. She was awarded the Natalie Weissberger Paul National Achievement Award from the National Society of Genetic Counselors in 2023.

Gregory Idos MD, MS

Associate Clinical Professor, Department of Medicine, Division of Gastroenterology

City of Hope

Dr. Idos is a board-certified gastroenterologist and trained cancer geneticist, who specializes in the care of patients with Lynch syndrome, FAP (familial adenomatous polyposis) and other inherited syndromes. The goal of his research is to find new ways to prevent cancer and to improve treatment and care for cancer patients.

A UCLA graduate, Dr. Idos has a master’s degree from Keck School of Medicine of USC. He received his medical degree at University of Vermont, continued his residency training at USC and completed his gastroenterology fellowship at Brigham and Women’s Hospital at Harvard. Dr. Idos is an associate clinical professor in Division of Gastroenterology and leads one of the largest multicenter studies examining the benefits and harms of “multiplex” gene panel testing. His research also focuses on the evaluation of novel technologies with the goal of providing new tools for hereditary cancer risk assessment and the development of novel cellular models to elucidate the fundamental mechanisms of microsatellite instability and Lynch syndrome.

Sandra Dreike, MS, CGC

Manager, Genetic Counselor

City of Hope

SANDRA DREIKE, MS, CGC is a licensed board-certified genetic counselor who specializes in cancer genetics. Sandra joined the City of Hope Division of Clinical Cancer Genomics in 2019, where she provides genetic counseling and cancer genetic risk assessments as a Senior Genetic Counselor. She received her Master of Science degree is Genetic Counseling from University of California, Irvine and her bachelor’s degree in Biology from California Polytechnic State University, San Luis Obispo. She previously practiced as a genetic counselor in Honolulu, HI where she specialized in cancer genetics and general pediatric and adult genetics. In addition to patient care she is a faculty member of the City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice, and research. Sandra is a member of the National Society of Genetic Counselors (NSGC) and Southern California Genetic Counselors (SCGC).

Lauren Gima, MS, CGC

Senior Genetic Counselor

City of Hope

LAUREN GIMA, MS, CGC is a board-certified, licensed genetic counselor at City of Hope in Duarte, CA, where she specializes in clinical cancer genomics. She earned her MS degree in Genetic Counseling from Northwestern University and BS degree in Human Biology from University of California San Diego. Her primary clinical responsibilities include providing cancer genetic counseling services for City of Hope’s patient population and her primary research interest is in hereditary GI cancer syndromes. Ms. Gima is a faculty member of the City of Hope Intensive Course and Clinical Cancer Genomics Community of Practice, and an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics masters’ programs. She serves as a clinical rotation supervisor for genetic counseling students and as a mentor for the KGI Genetic Counseling program, providing ongoing support and guidance for new genetic counseling students. Lauren is a member of the National Society of Genetic Counselors, the Collaborative Group of the Americas on Inherited Gastrointestinal Cancers, the Southern California Genetic Counselors, the Minority Genetics Professionals Network, and the Alliance for Genomic Justice.

Rachelle Manookian, MS, CGC

Genetic Counselor

Children's Hospital of Los Angeles

RACHELLE MANOOKIAN, MS, CGC is a licensed and board-certified cancer genetic counselor specializing in pediatric oncology at Children’s Hospital Los Angeles (CHLA). She was previously with the Division of Clinical Cancer Genomics at City of Hope, and before that, a general genetic counselor at the West VA Medical Center. She brings her growing expertise in medical education to her role as an adjunct faculty member for the Keck Graduate Institute Genetic Counseling and Genomic Data Analytics master’s programs. She serves as a faculty mentor, graduate capstone supervisor, and rotation supervisor for current genetic counseling students. She is actively engaged in the Fanconi anemia community and has been a volunteer at Fanconi Anemia Family Week since 2016, and she is a two-time nominee of the Heart of Genetic Counseling Award from the National Society of Genetic Counselors.

 

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